CHIME: Scalable CMOS technology for volumetric deep brain recording
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1
Francis Crick Institute, United Kingdom
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2
University College London, United Kingdom
Information in the mammalian brain is distributed across sheets of millions of neurons spanning millimetres to centimetres, in structures such as neocortex or hippocampus. Current recording techniques can capture only a tiny fraction of this information at millisecond timescale - typically along a single or few “tunnels” around electrode shanks.
Here we propose a new strategy for scalable neuronal recording by combining bundles of insulated microwires with CMOS amplifier arrays. We show that the CMOS Hosted In-vivo MultiElectrodes (CHIME) technique records LFP and unit activity from deep volumes with minimal tissue damage. Electrodes can be flexibly distributed in space; different types of microwires can be combined with various recording arrays including those derived from commercial high-speed infrared sensors.
Thus, this approach ties the progress of electrical neuronal recording to the rapid scaling of consumer electronics. It lifts a two dimensional CMOS architecture into the third dimension and can be translated to other arrays such as electrical stimulation devices.
Keywords:
CMOS,
in-vivo neural recording,
in-vivo,
large-scale,
Electrophysiology
Conference:
MEA Meeting 2018 | 11th International Meeting on Substrate Integrated Microelectrode Arrays, Reutlingen, Germany, 4 Jul - 6 Jul, 2018.
Presentation Type:
Oral Presentation
Topic:
In vivo applications of MEAs
Citation:
Kollo
M
(2019). CHIME: Scalable CMOS technology for volumetric deep brain recording.
Conference Abstract:
MEA Meeting 2018 | 11th International Meeting on Substrate Integrated Microelectrode Arrays.
doi: 10.3389/conf.fncel.2018.38.00067
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Received:
26 Mar 2018;
Published Online:
17 Jan 2019.
*
Correspondence:
MD, PhD. Mihaly Kollo, Francis Crick Institute, London, United Kingdom, kollom@crick.ac.uk