Primary Progressive Aphasia: State-of-the-Science Symposium
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Johns Hopkins Medicine, United States
Organizer: Kyrana Tsapkini, PhD, Johns Hopkins University
Participants: Marsel Mesulam, MD, Cynthia Thompson, PhD, Maria-Luisa Gorno-Tempini, MD, PhD, Argye B. Hillis, MD, MA, Maya Henry, PhD, and Kyrana Tsapkini, PhD
The purpose of this symposium is to discuss the state-of-the-science in Primary Progressive Aphasia based on findings from three major research laboratories: Northwestern University (NU), the University of California at San Franscisco (UCSF), and Johns Hopkins University (JHU). Dr. Marsel Mesulam (NU) will begin with an overview of the history of PPA and PPA variants. Following this Drs. Cynthia Thompson (NU), Marilu Gorno Tempini (UCSF) and Argye Hillis (JHU), will present findings from the three research laboratories, respectively, focused on patterns of language impairment and associated neural atrophy in PPA. Two speakers, Drs. Maya Henry and Kyrana Tsapkini, also will present the results of research examining the effects of treatment for people with PPA, with talks focusing on the effects of neural stimulation and other intervention approaches. Finally, Dr. Mesulam will discuss current clinical and research challenges and future research directions in PPA.
Dr. Mesulam, is the Ruth Dunbar Davee Professor of Neuroscience and the Director of Cognitive Neurology and Alzheimer’s Disease Center at Northwestern University. He has researched extensively a wide range of neurogenic disorders focusing on several topics from memory to language, from aging to Alzheimer’s to epilepsy. He is responsible for coining the term ‘primary progressive aphasia’ and inaugurating all the research in the field. He will present on that history, current challenges and future directions in the field.
Dr. Thompson is the Ralph and Jean Sundin professor of Communication Sciences, Professor of Neurology, and Director of the Center for the Neurobiology of Language Recovery (CNLR) at Northwestern University. Her research focuses on normal and disordered language processing in aphasia (both stroke-induced and PPA) and how language recovers or declines in the two, respectively. Her work uses eyetracking, EEG, and fMRI to examine patterns of language breakdown and recovery and their neural correlates, with a primary focus on sentence processing. Together with Dr. Mesulam and others at Northwestern, she has published many studies focus on PPA. She will present on neurocognitive deficits associated with progressive grammatical impairments.
Dr. Gorno Tempini, professor of neurology at UCSF, is a behavioral neurologist with a doctorate degree in imaging neuroscience and currently directs the Language & Neurobiology Laboratory at the UCSF Memory and Aging Center (MAC). Dr. Gorno Tempini’s main focus is in behavioral neurology, particularly the neural basis of higher cognitive functions such as language and memory. She has applied her expertise in cognitive neurology and neuroimaging to the study of neurodegenerative disease, in particular primary progressive aphasia (PPA) and frontotemporal dementia (FTD). In this symposium she will present on recent neuroimaging findings on PPA markers and progression from different imaging modalities.
Dr. Hillis is professor of Neurology at JHU, with joint faculty appointments in Physical Medicine and Rehabilitation and in Cognitive Science. Prior to medical training and neurology residency, Dr. Hillis worked as a speech-language pathologist, and conducted clinical research focusing on understanding and treating aphasia. Her expertise lies in the characterization and treatment of aphasia using imaging and behavioral techniques. She is the director of the PPA clinic at Johns Hopkins University. She will present on clinical perspectives and classification issues in the characterization of PPA.
Dr. Henry is assistant professor at the school of communication sciences and disorders at the University of Texas at Austin and continues to be affiliated with UCSF’s Memory and Aging Center. Dr. Henry's clinical and research interests are in the nature and treatment of aphasia and related neurogenic communication disorders. In her research she has explored cognitive and neural bases of spoken and written language as well as the rehabilitation of language impairments associated with primary progressive aphasia. She will present on the state-of-the-art in behavioral speech-language interventions in PPA.
Dr. Tsapkini is assistant professor of neurology at Johns Hopkins University. She is neuropsychologist by training with specialization in language and has investigated language breakdown from different etiologies using behavioral and imaging techniques. In the recent years she has been conducting oral and written interventions to study the efficacy of trancranial direct current stimulation (tDCS) in slowing down the rate of language decline in PPA. She will present on the state-of-the-art of neuromodulation attempts in PPA.
Keywords:
primary progressive aphasia,
clinical perspectives,
tDCS and rehabilitation,
Treatment,
Neuroimaging,
Classification
Conference:
Academy of Aphasia 55th Annual Meeting , Baltimore, United States, 5 Nov - 7 Nov, 2017.
Presentation Type:
symposium
Topic:
General Submission
Citation:
Tsapkini
K
(2019). Primary Progressive Aphasia: State-of-the-Science Symposium.
Conference Abstract:
Academy of Aphasia 55th Annual Meeting .
doi: 10.3389/conf.fnhum.2017.223.00023
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Received:
03 May 2017;
Published Online:
25 Jan 2019.
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Correspondence:
Dr. Kyrana Tsapkini, Johns Hopkins Medicine, Baltimore, United States, tsapkini@jhu.edu