Co-evolution of neurons and glia during ageing in C. elegans
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1
ULB Neuroscience Institute, Free University of Brussels, Belgium
The co-evolution of glial cells with neurons during ageing is relatively unexplored. The amphid sensory system of C. elegans offers a great opportunity to study this in-vivo. A highly coordinated neuro-glial structure is required for the amphid sensory functions: the amphid glial cells embed the sensory terminals of 12 sensory neurons responsive to the environment. However, what happens to this ensemble during ageing and pathology has not been studied. To this end, we are creating models to study the morphological and functional co-evolution of glia and neurons longitudinally during physiological and pathological ageing.
To this end, we are using mutant backgrounds involving overrepresented genes involved in neuron-glia communication functions, and several important pathways that could be involved in the coupling of both cellular types.
Taking advantage of C. elegans short lifespan, powerful genetics, and simplicity of the glia-neuron relationship, the morphology and function of both glia and neurons will be characterised over age. Using tools like GFP-tagging, microscopy, cellular ablation, calcium imaging and behavioural assays, we will explore candidate mechanisms driving the glia-neuron relationship.
Keywords:
glia,
Neuron,
Amphid,
Ageing,
Cell Communication
Conference:
13th National Congress of the Belgian Society for Neuroscience , Brussels, Belgium, 24 May - 24 May, 2019.
Presentation Type:
Poster presentation
Topic:
Cellular/Molecular Neuroscience
Citation:
Razzauti Sanfeliu
A
(2019). Co-evolution of neurons and glia during ageing in C. elegans.
Front. Neurosci.
Conference Abstract:
13th National Congress of the Belgian Society for Neuroscience .
doi: 10.3389/conf.fnins.2019.96.00037
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Received:
24 Apr 2019;
Published Online:
27 Sep 2019.
*
Correspondence:
Mx. Adrià Razzauti Sanfeliu, ULB Neuroscience Institute, Free University of Brussels, Brussels, Belgium, arazzaut@ulb.ac.be