Report of the use of topical ozone together with professional oral hygiene procedures in patient with gingival mucous membrane pemphigoid
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1
University of Turin, Department of Surgical Sciences, Oral Medicine Section, Italy
Aim.
Mucous membrane pemphigoid (MMP) is a heterogeneous group of autoimmune chronic inflammatory, subepithelial blistering disorder, predominantly involving the mucous membranes. It has a female predilection and commonly occurring after the fifth decade of life. The oral mucosa is affected in more than 90% of cases. Even if this condition has been reported as non-plaque induced, effective dento-gingival plaque control sometimes could resolve the gingival inflammation. Ozone is naturally produced by the photo dissociation of molecular oxygen into activated oxygen atoms which then react with further oxygen molecules. This transient radical anion rapidly becomes protonated, which in turn decomposes to an even powerful oxidant, the hydroxyl radical OH. Application of ozone in periodontics comes as a result of its physic-chemical properties. Ozone therapy has a wide range of applications in treating various diseases owing to its unique properties including antimicrobial, immunostimulant, analgesic, detoxicating, bioenergetic and biosynthetic actions.
Materials and Methods.
A 70-year-old female patient presented with 1-year history of intact blisters in her mouth, which ruptured leaving throbbing ulcers and peeling of the gingiva; she also reported pain and burning sensation while taking hot and spicy foods. A biopsy was performed with MMP evidence. A professional oral hygiene regimen was started to deal with the gingival status associated together with the use of local ozone applications. Severity of pain was detailed using a Visual Analogue Scale (VAS). Patient received non-surgical periodontal therapy, including personalized oral hygiene instructions, and thorough supragingival scaling and polishing with the removal of all deposits and staining. Clinical outcome variables were recorded at baseline and after the intervention and included full-mouth plaque scores (FMPS), full-mouth bleeding scores (FMBS), and the clinical extension of gingival involvement.
Results.
After finishing the proposed protocol, a significant and statistical reduction was observed for FMPS, FMBS, and clinical gingival involvement, without using any topical or systemic immunosuppressant.
Discussion.
Professional oral hygiene procedures and non-surgical periodontal therapy, including topical use of ozone therapy, were associated with a prominent improvement of gingival clinical outcomes in this female with exclusive MMP related gingivitis.
References
1. Arduino PG, Farci V, D'Aiuto F, et al. Periodontal status in oral mucous membrane pemphigoid: initial results of a case-control study. Oral Dis. 2011;17:90-94.
2. Arduino PG, Lopetuso E, Carcieri P, et al. Professional oral hygiene treatment and detailed oral hygiene instruction in patients affected by mucosa membrane pemphigoid with specific gingival localization in 12 patients. Int J Dent Hyg. 2012;10:138-141.
3. Gupta G, Mansi B. Ozone therapy in periodontics. J Med Life. 2012;5:59-67.
Keywords:
Mucous membrane pemphigoid,
Oxone,
Plaque,
oral cavity,
Oral Hygiene
Conference:
5th National and 1st International Symposium of Italian Society of Oral Pathology and Medicine., Ancona, Italy, 19 Oct - 20 Oct, 2018.
Presentation Type:
Poster Presentation
Topic:
Oral Diseases
Citation:
Carcieri
P,
Broccoletti
R,
Gambino
A,
Conrotto
D,
Carbone
M and
Arduino
P
(2019). Report of the use of topical ozone together with professional oral hygiene procedures in patient with gingival mucous membrane pemphigoid.
Front. Physiol.
Conference Abstract:
5th National and 1st International Symposium of Italian Society of Oral Pathology and Medicine..
doi: 10.3389/conf.fphys.2019.27.00033
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Received:
11 Oct 2018;
Published Online:
09 Dec 2019.
*
Correspondence:
Dr. Paola Carcieri, University of Turin, Department of Surgical Sciences, Oral Medicine Section, Turin, Piedmont, 10124, Italy, marcomascitti86@hotmail.it