Exploring correlations between blood pressure variation and mood instability in bipolar disorder and borderline personality disorder.
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1
University of Oxford, Department of Psychiatry, United Kingdom
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2
University of Oxford, Department of Psychiatry, United Kingdom
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3
University of Oxford, Institute of Biomedical Engineering, United Kingdom
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4
University of Oxford, Mathematical Institute, United Kingdom
Bipolar disorder (BD) is a mood disorder characterised by episodes of elation and depression. Cardiovascular disease (CVD) is the biggest single cause of premature death in people with BD and accounts for over a third of all deaths in this cohort. BD is associated with a cardiovascular mortality risk twice that of the general population. The mechanisms underlying this increased risk are largely unknown. Here, potential associations between BD and CVD risk factors were investigated in people with BD, and were compared against a clinical control group with borderline personality disorder (BPD) and a healthy control group (HC). Participants recorded their blood pressure three times a day and reported their mood status using a bespoke mobile application. Depressive and manic symptoms were also assessed using clinical questionnaires. Mood and blood pressure varied significantly between the three groups. Pulse pressure was greater in those with BD than the BPD group. The extent and variability of negative moods were greater in the clinical groups than the HC group, with the values being highest in those with BPD. Positive mood was most variable in those with BPD. The BD group showed positive correlations between blood pressure measures and negative mood states, while those in the HC cohort had only negative correlations between blood pressure and positive mood variability. These findings suggest that negative moods may have a detrimental effect on blood pressure, potentially through stress-related, cortisol and sympathetic responses, while positive moods have the converse effect. Increasing focus on physiological measures, such as blood pressure, in those with BD and emphasising the importance of mood stabilisation may help to improve cardiovascular health in this vulnerable cohort.
Acknowledgements
The study was supported by the Wellcome Trust through a Centre Grant no. 98,461/Z/12/Z, “The University of Oxford Sleep and Circadian Neuroscience Institute (SCNi)”. This work was also funded by a Wellcome Trust Strategic Award (CONBRIO: Collaborative Oxford Network for Bipolar Research to Improve Outcomes, Reference number 102,616/Z). NP and MO acknowledge the support of the RCUK Digital Economy Programme Grant number EP/G036861/1 (Oxford Centre for Doctoral Training in Healthcare Innovation
Keywords:
Bipolar Disorder,
Borderline Personality Disorder,
Affective Disorders,
Personality Disorders,
Cardiovascular disease (CVD),
Cardiovascular disease risk factors,
Blood Pressure,
Blood Pressure Monitoring, Ambulatory,
Mood Disorders,
Mood monitoring,
self monitoring,
mood states,
QIDS-SR,
Depression,
ASRM,
Altman Self-rating Mania Scale,
mania,
Correlation,
Prinicpal Component Analysis,
RMSSD,
Comorbidity,
Somatic disease,
Mortality,
Psychiatry,
clinical practice,
android app development
Conference:
ISAD LONDON 2017: Perspectives on Mood and Anxiety Disorders: Looking to the future, London, United Kingdom, 6 Jul - 7 Jul, 2017.
Presentation Type:
Poster
Topic:
Comorbidity between mood disorders and somatic disorders
Citation:
Nichols
MM,
Saunders
KE,
Atkinson
LZ,
Bilderbeck
AC,
Carr
O,
Athanasios
T,
Palmius
N,
Geddes
J and
Goodwin
GM
(2019). Exploring correlations between blood pressure variation and mood instability in bipolar disorder and borderline personality disorder..
Front. Psychiatry.
Conference Abstract:
ISAD LONDON 2017: Perspectives on Mood and Anxiety Disorders: Looking to the future.
doi: 10.3389/conf.fpsyt.2017.48.00018
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Received:
26 May 2017;
Published Online:
25 Jan 2019.
*
Correspondence:
Miss. Molly M Nichols, University of Oxford, Department of Psychiatry, Oxford, OX1 4AW, United Kingdom, molly.nichols@queens.ox.ac.uk