Obesity, insulin resistance and the rice you eat: Any link?
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1
Usmanu Danfodiyo University, Nigeria
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2
Institute of Bioscience, University Putra Malaysia, Malaysia
Background
Type 2 diabetes is a metabolic disorder with established, well-defined precursors. Obesity and insulin resistance are amongst most important factors in predisposition to diabetes. Rice is a staple for about half the global population and its consumption has been strongly linked with diabetogenesis. We assert that tackling the prevalence of predisposing factors by modifying certain rice cultivars could reduce the global burden of obesity and insulin resistance, and by extension type 2 diabetes.
Methods
Several rice cultivars with various properties were fed to nulliparous rats (five weeks old at the start of the experiment) for 90 days. They were then returned to a diet of standard pellets and mated with males on a standard diet. The resulting pups and dams were investigated for obesity and insulin resistance markers.
Results
We found that germination caused reduce predisposition to obesity and insulin resistance than high amylose content. The combined reducing effect of germination and high amylose content on predisposition to obesity and insulin resistance was greater than the sum of their independent effects. Polished (white) rice with a low amylose content predisposed dams on a high-fat diet to markers of insulin resistance and obesity and this predisposition was inherited by their F1 offspring.
Conclusion
Overall, the results suggest that harnessing the beneficial properties of germination and amylose in rice would reduce the burden of obesity and insulin resistance, which are known to be key risk factors for development of type 2 diabetes.
Keywords:
Obesity,
Insulin Resistance,
Germinated brown rice,
Amylose content,
type 2 diabetes
Conference:
International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18)
“Seizing Opportunities and Addressing Challenges of Precision Medicine”, Putrajaya, Malaysia, 3 Dec - 5 Feb, 2019.
Presentation Type:
Oral Presentation
Topic:
Metabolic diseases
Citation:
Abubakar
B,
Zawawi
N,
Omar
AR and
Ismail
M
(2019). Obesity, insulin resistance and the rice you eat: Any link?.
Front. Pharmacol.
Conference Abstract:
International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18)
“Seizing Opportunities and Addressing Challenges of Precision Medicine”.
doi: 10.3389/conf.fphar.2019.63.00013
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Received:
14 Oct 2018;
Published Online:
17 Jan 2019.
*
Correspondence:
Dr. Bilyaminu Abubakar, Usmanu Danfodiyo University, Sokoto, Nigeria, abu3163abu@yahoo.co.uk