Novel strontium ranelate containing microparticles for the treatment of osteoporotic bone fractures
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1
Faculty of Materials Science and Applied Chemistry, Riga Technical University, Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Latvia
Fragility of large bone fracture defects produce challenges in operative stabilization and treatment of osteoporotic fractures, opening new possibilities for multifunctional drug releasing composites. In last decade, mechanisms of action and efficiency of strontium ions and strontium ranelate have been intensively investigated. Strontium ranelate is used in the treatment of a variety of bone diseases characterised by osteoclast-mediated bone resorption and at the same time promoting osteoblast bone formation. However, per-oral administration of strontium ranelate can cause some toxic side effects on the gastro enteric tract, liver and heart. Therefore, local drug delivery forms could overcome these side effects and increase the drug efficiency.
Within the current research for the first time a novel microencapsulated drug delivery system was prepared and evaluated. Strontium ranelate loaded poly (lactic acid) microcapsules were prepared using slightly modified water-in-oil-in-water microencapsulation technique. Strontium ranelate was encapsulated in the PLA matrix. Additionally nanosized hydroxyapatite particles were used in the encapsulation process to modify the surface and properties of obtained PLA/strontium ranelate microcapsules. It was found that drug was released within 1 month if microcapsules with more than 20wt% of strontium ranelate were used. Decreasing the strontium ranelate content in microcapsules down to 3wt%, drug was gradually released for more than 2 month. If nanosized hydroxyapatite (NHAp) particles were used in the encapsulation process, drug release profile was signifficantly influenced.
Keywords:
Bone Regeneration,
Drug delivery,
Biodegradable material,
Nano/micro particle
Conference:
10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016.
Presentation Type:
Poster
Topic:
Biomaterials for therapeutic delivery
Citation:
Loca
D,
Smirnova
A,
Locs
J and
Berzina-Cimdina
L
(2016). Novel strontium ranelate containing microparticles for the treatment of osteoporotic bone fractures.
Front. Bioeng. Biotechnol.
Conference Abstract:
10th World Biomaterials Congress.
doi: 10.3389/conf.FBIOE.2016.01.00272
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Received:
28 Mar 2016;
Published Online:
30 Mar 2016.