Biocompatibility and mineralization of osteoblastic cells in contact with niobium
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1
University of São Paulo, Bioengineering, Brazil
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2
Federal University of São Carlos, Brazil
Niobium has the potential to be a metal with wide applicability in engineering and in the medical field; but the medical literature regarding the behavior of this material is scarce. It is required to evaluate the biocompatibility and mineralization of the niobium element (94,47% purity) if it would be used as an implant material. Therefore, it is important to understand the cellular and molecular events that occur in the material-cell interface. The biocompatibility and mineralization of the organic material in contact with the niobium element was evaluated though laboratory techniques such as AlamarBlue and Alizarin Red staining, as well as the expression of genes important in the osteoblastic mineralization and maintenance of cells by qPCR technique. Niobium is a biocompatible metal and has osteointegrative properties. The cells in direct contact with the material obtained a cellular activity indifferent to the control (without Nb), moreover, the surface of the material allowed affixing calcium deposits, proving its osteoinduction, osteogenesis and osteoconduction. The gene expression allowed to prove statistically that niobium is prone for implant materials.
References:
[1] Matsuno H, Yokoyama A, Watari F, Uo M, Kawasaki T
Keywords:
in vitro,
biomaterial,
Implant,
Biocompatibility
Conference:
10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016.
Presentation Type:
Poster
Topic:
Cellular migration and biomaterials
Citation:
Molin
P,
Selistre De Araújo
HS and
Almeida Rollo
JD
(2016). Biocompatibility and mineralization of osteoblastic cells in contact with niobium.
Front. Bioeng. Biotechnol.
Conference Abstract:
10th World Biomaterials Congress.
doi: 10.3389/conf.FBIOE.2016.01.00816
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Received:
27 Mar 2016;
Published Online:
30 Mar 2016.