The researches on cells adhesion on the biocompatible polymer surface with superwettability
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1
State Key Laboratory of Supramolecular Structure and Materials, Jilin University, China
The realization on controlling cells behaviors by engineering the surface superwettability has attracted more and more research interests. For the superhydrophobic surface, the cells adhesion was inhibited on the superhydrophobic polylactic acid surface in the first 24h culture; and there was no obvious inhibiting effect on the superhydrophilic surface[1]. Due to the complexity and specificity of the interaction between cells and materials, we further investigated the adhesive behaviors of different cell lines, such as L929, SaOs2 and ATDC5, on the superhydrophobic polystyrene surface[2],[3]. The results showed that all these three cell lines could adhesion on the superhydrophobic PS surface in long time culture; but the proliferation of SaOs2 and ATDC5 could not occur, L929 cells exhibited well proliferated rate. Regarding to the superhydrophilic surface, especially for porous chitosan scaffold surface with ultrafast spreading property, cells could be trapped in the scaffold quickly; the cells adhesion, growth and proliferation were improved combined with UV irradiation[4]. It will shorten the trapped time of cells into scaffold, sequentially decrease the cured time for the patients. The method of constructing ultra-fast spreading property on the porous scaffold surface will offer more simple way on fabricating excellent tissue engineering scaffolds.
Figure 1. Schematic illustration of cells adhesion on the superhydrophobic and superhydrophilic surface.
This work is supported by the National Research Fund for Fundamental Key Projects (2012CB933800); the National Natural Science Foundation for the Youth of China (21204026 and 81400488).
References:
[1] W. L. Song, D. D. Veiga, C. A. Custódio, J. F. Mano, Adv. Mater. 2009, 21, 1830-1834.
[2] S. M. Oliveira, W. L. Song, N. M. Alves, J. F. Mano, Soft Matter, 2011, 7, 8932-8941;
[3] W. L. Song* and J. F. Mano*, Soft Matter, 2013, 11, 2985-2999.
[4] C.M. Wang, C. Y. Qiao, W. L. Song, H. C. Sun, ACS Appl. Mater. Interfaces, 2015, 7(32), 17545-17551.
Keywords:
Hydrogel,
Tissue Engineering,
Biomimetic,
Surface modification
Conference:
10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016.
Presentation Type:
New Frontier Oral
Topic:
Surface and interfacial characterization
Citation:
Wang
C,
Wang
J and
Song
W
(2016). The researches on cells adhesion on the biocompatible polymer surface with superwettability.
Front. Bioeng. Biotechnol.
Conference Abstract:
10th World Biomaterials Congress.
doi: 10.3389/conf.FBIOE.2016.01.01348
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Received:
27 Mar 2016;
Published Online:
30 Mar 2016.
*
Correspondence:
Dr. Chenmiao Wang, State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, China, cmwang12@mails.jlu.edu.cn
Dr. Jian Wang, State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, China, 423900309@qq.com
Dr. Wenlong Song, State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, China, songwenlong@jlu.edu.cn