Design of biocompatible polymers: The roles of bio-interfacial water and "intermediate water" concept
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1
Kyushu University, Institute for Materials Chemistry and Engineering, Japan
In biomedical applications, there are continuous efforts to enhance methods, materials, and devices. The recent development of soft-biomaterials and their applications to biomedical problems have dramatically improved the treatment of many diseases and injuries. Although a various types of materials in biomedicine have been used widely, most biomaterials lack the desired functional properties to interface with biological systems and have not been engineered for optimum performance. Therefore, there is an increasing demand to develop novel soft-materials to address such problems in biomedicine arena. There are numerous parameters of polymeric biomaterials that can be affected the cellular behavior in a controlled manner. The underlying mechanisms for the biocompatibility of polymers at the molecular level are complex and have not been clearly demonstrated, although many theoretical and experimental efforts have been made to understand these mechanisms. Water and proteins interactions have been recognized as fundamental for the biological response to contact with polymers. We have proposed the “Intermediate Water” concept; the water exhibited clearly defined peaks for cold crystallization in the differential scanning calorimetry chart, a strong peak at 3400 cm-1 in a time-resolved Infrared spectrum and higher mobility of water in a ²H-NMR. The intermediate water was only found in hydrated biopolymers (proteins, polysaccharides and nucleic acid; DNA and RNA) and hydrated biocompatible synthetic polymers. The intermediate water behaves differently from bulk water and acts as a physical barrier against protein adsorption and platelet adhesion. We hypothesized that intermediate water, which prevents the proteins and blood cells from directly contacting the polymer surface on the polymer surface, plays an important role in the biocompatibility of polymers. Our findings offer a comprehensive description of the design of the multi-functional biomedical polymers by controlling bio-interfacial water structure through precision polymer synthesis.
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Keywords:
Cell Adhesion,
Biocompatibility,
surface property,
bioinerface
Conference:
10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016.
Presentation Type:
Poster
Topic:
Protein interactions with biomaterials
Citation:
Tanaka
M
(2016). Design of biocompatible polymers: The roles of bio-interfacial water and "intermediate water" concept.
Front. Bioeng. Biotechnol.
Conference Abstract:
10th World Biomaterials Congress.
doi: 10.3389/conf.FBIOE.2016.01.01418
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Received:
27 Mar 2016;
Published Online:
30 Mar 2016.