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Electroconductive hydrogel based on bacterial cellulose for 2D and 3D cell culture

Zhijun Shi1, 2, Sixiang Li1, 2 and Guang Yang1, 2
  • 1 Huazhong University of Science & Technology, Department of Biomedical Engineering, College of Life Science & Technology, China
  • 2 Huazhong University of Science & Technology, Nationl Engineering Research Center for Nano-Medicine, China

New generations of biomaterials which have multiple chemical and physical functions are being developed for regenerative medicine and tissue engineering direct cellular behavior and function. Functional biomaterials can smart regulate microenvironments (including stiffness, pore size, cell-matrix interactions, or response with the electric signal) of cells, to promotes cell migration, differentiation and remodeling of the gel matrix. Many different forms of extracellular signaling cues are used during development, regeneration, and wound healing to generate pattern and organization. Endogenous DC electric fields (EFs) are one such signaling of development, regeneration, and wound healing. The fields are the result of polarized ion transport and current flow through electrically conductive pathways. The electroconductive hydrogel is a biocompatible electrically conductive pathway to help tissue regeneration, especially in neuron regeneration and wound healing.  Hereby, we report on freestanding, flexible electroactive hydrogel based on bacterial cellulose(BC) and polypyrrole(PPy), the electroactive hydrogel which have good mechanical property and good conductivity, which can be used in neuron regeneration and wound healing.

This work was supported by the National Natural Science Foundation of PR China (21074041, 31270150).

References:
[1] Li S. , Huang D., Zhang B. , Xu X., Wang M. *, Yang G. *, Shen Y.*, Flexible Supercapacitors Based on Bacterial Cellulose Paper Electrodes, Adv. Energy Mater. , 2014, 4, 1301655-61.
[2] Shi Z, Phillips GO, Yang G.*, Nanocellulose Electroconductive Composites, Nanoscale, 2013, 5: 3194-201.
[3] Shi Z, Li Y, Chen X, Han H, Yang G.*, Double Network Bacterial Cellulose Hydrogel to Build a Biology–device Interface, Nanoscale, 2014, 6: 970-7.

Keywords: nanocomposite, Biocompatibility, electric, 3D scaffold

Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016.

Presentation Type: General Session Oral

Topic: Nano-structured materials for unique functions

Citation: Shi Z, Li S and Yang G (2016). Electroconductive hydrogel based on bacterial cellulose for 2D and 3D cell culture. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.01466

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Received: 27 Mar 2016; Published Online: 30 Mar 2016.