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Synergistic antibacterial effects mediated by graphene/iron oxide-based nanocomposites

Hsing-Wen Sung1, 2*, Wen-Yu Pan1*, Chieh-Cheng Huang1*, Tzu-Tsen Lin1*, Hsin-Yi Hu1*, Wei-Chih Lin1* and Meng-Ju Li3*
  • 1 National Tsing Hua University, Department of Chemical Engineering, Taiwan
  • 2 National Tsing Hua University, Institute of Biomedical Engineering, Taiwan
  • 3 National Taiwan University Hospital Hsinchu Branch, Department of Pediatrics, Taiwan

This work develops a composite system of reduced graphene oxide (rGO)-iron oxide nanoparticles (rGO-IONP) that can synergistically induce physical and chemical damage to methicillin-resistant Staphylococcus aureus (MRSA) that are present in subcutaneous abscesses. rGO-IONP was synthesized by the chemical deposition of Fe2+/Fe3+ ions on nanosheets of rGO in aqueous ammonia. The antibacterial efficacy of the as-prepared rGO-IONP was evaluated in a mouse model with MRSA-infected subcutaneous abscesses. Upon exposure to a near-infrared laser in vitro, rGO-IONP synergistically generated localized heat and large amounts of hydroxyl radicals, which inactivated MRSA. The in vivo results reveal that combined treatment with localized heat and oxidative stress that is caused by hydroxyl radicals accelerated the healing of wounds associated with MRSA-infected abscesses. The above results demonstrate that an rGO-IONP nanocomposite system that can effectively inactivate multiple-drug-resistant bacteria in subcutaneous infections was successfully developed.

Keywords: Bacteria, temperature, biomedical application, Polymeric material

Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016.

Presentation Type: Poster

Topic: Biomaterials in wound care

Citation: Sung H, Pan W, Huang C, Lin T, Hu H, Lin W and Li M (2016). Synergistic antibacterial effects mediated by graphene/iron oxide-based nanocomposites. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.01627

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Received: 27 Mar 2016; Published Online: 30 Mar 2016.

* Correspondence:
Dr. Hsing-Wen Sung, National Tsing Hua University, Department of Chemical Engineering, Hsinchu, Taiwan, Email1
Dr. Wen-Yu Pan, National Tsing Hua University, Department of Chemical Engineering, Hsinchu, Taiwan, Email2
Dr. Chieh-Cheng Huang, National Tsing Hua University, Department of Chemical Engineering, Hsinchu, Taiwan, Email3
Dr. Tzu-Tsen Lin, National Tsing Hua University, Department of Chemical Engineering, Hsinchu, Taiwan, Email4
Dr. Hsin-Yi Hu, National Tsing Hua University, Department of Chemical Engineering, Hsinchu, Taiwan, Email5
Dr. Wei-Chih Lin, National Tsing Hua University, Department of Chemical Engineering, Hsinchu, Taiwan, Email6
Dr. Meng-Ju Li, National Taiwan University Hospital Hsinchu Branch, Department of Pediatrics, Hsinchu, Taiwan, Email7