Evaluation of DESolve, a drug eluting bioresorbable scaffold in a porcine coronary artery model
-
1
AccelLAB Inc., Canada
-
2
Elixir Medical, United States
The PLLA based totally bioresorbable drug eluting scaffold, DESolve, was imaged by Optical Coherence Tomography (OCT) following implantation in a porcine coronary artery model to characterize the scaffold with regard to acute recoil, vessel support and bioresorption. Pigs were implanted with 3.0 x 14 mm DESolve scaffolds in the healthy coronary arteries and were OCT imaged at multiple time points post implantation up to 720 days. Quantitative morphometric measurements based on angiographic and OCT images were performed to evaluate the behavior of the scaffold at these time points. Angiographically the average % diameter stenosis was low and did not change significantly up to the two year time point. OCT measurements recorded 30 min after device implantation showed that there was minimal acute recoil and the device was able to provide the recommended luminal support up to the 90 day time point. The strut foot prints were discernible at the one year time point although by the two year time point it was difficult to locate significant strut footprints in OCT pull back images demonstrating the near complete bioresorption of the device by this time point. This observation was further complimented through histochemical analysis of the explanted vessel. Histological cross sections of the scaffold implanted vessel segment at the 2 yr time point showed that most of the strut voids had been replaced by extracellular matrix with very few identifiable strut voids as determined by alcian blue staining. Thus both OCT and histology confirmed the near complete bioresorption of the DESolve scaffold along with the integration of the struts into the arterial wall by the 2 year time point.
Keywords:
Drug delivery,
blood vessel,
3D scaffold,
Biodegradable material
Conference:
10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016.
Presentation Type:
Poster
Topic:
Drug-eluting devices
Citation:
Guy
L,
Horng
S,
Laflamme
M,
Savard
C,
Ramesh
N,
Huang
H,
Patel
A,
Yan
J,
Leclerc
G and
Bhat
V
(2016). Evaluation of DESolve, a drug eluting bioresorbable scaffold in a porcine coronary artery model.
Front. Bioeng. Biotechnol.
Conference Abstract:
10th World Biomaterials Congress.
doi: 10.3389/conf.FBIOE.2016.01.02456
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Received:
27 Mar 2016;
Published Online:
30 Mar 2016.