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One-step fabrication of polymeric hybrid particles with various anisotropic architectures via a microfluidic-assisted phase separation process and their application in controllable drug delivery

Hua Dong1, 2, Wenxiu Li1 and Xiaodong Cao1, 2
  • 1 School of Materials Science and Engineering, South China University of Technology, Department of Biomedical Engineering, China
  • 2 South China University of Technology, National Engineering Research Center for Tissue Restoration and Reconstruction, China

We report herein a one-step route to fabricate core-shell, patchy, patchy Janus and Janus particles via microfluidic-assisted phase separation process.

As a proof of concept, PLGA/PCL hybrid particles are prepared and the results show that the four types of particles can be harvested with high yield and narrow size distribution by precise control over the phase separation process, or namely, interfacial tensions and spreading coefficients between immiscible phases, after generation of the single emulsion in microchannels[1].

The applications of Janus and core-shell particles in drug delivery are characterized via in vitro degradation behaviors, implying their capability of programmable drug delivery in different manners[2].

This research work was financially sponsored by the National Natural Science Foundation of China (Grant NO. 51373056, 51372085), Guangdong-Hongkong common technology bidding project (No.2013B010136003) and Fundamental Research Funds for the Central Universities.

References:
[1] Xiaodong Cao, Wenxiu Li, Ting Ma, Hua Dong*, One-step fabrication of polymeric hybrid particles with core-shell, patchy, patchy Janus and Janus architectures via microfluidic-assisted phase separation process. RSC Advances. 2015, 5, 79969-79975.
[2] Wenxiu Li, Hua Dong*, Guannan Tang, Ting Ma, Xiaodong Cao*, Controllable microfluidic fabrication of Janus and microcapsule particles for drug delivery application. RSC Advances. 2015, 5, 23181-23188.

Keywords: Drug delivery, Bio-MEMS, Biodegradable material, Polymeric material

Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016.

Presentation Type: Poster

Topic: Combinatorial approaches to biomaterial design

Citation: Dong H, Li W and Cao X (2016). One-step fabrication of polymeric hybrid particles with various anisotropic architectures via a microfluidic-assisted phase separation process and their application in controllable drug delivery. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.02524

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Received: 27 Mar 2016; Published Online: 30 Mar 2016.