Fabrication and characterization of hydrocolloid dressing with silk fibroin nanoparticle for wound healing
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1
Hallym University, Nano-Bio Regenerative Medical Institute, Korea
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2
Chonbuk National University, Department of BIN Fusion Technology, Korea
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3
Chuncheon Sacred Heart Hospital, Departments of Otorhinolaryngology-Head and Neck Surgery, Korea
Hydrocolloid dressings have been developed for many types of wound healing. In particular, dressing is a critical component in the successful recover of burn injuries, which causes a great number of people to not only suffer from physical but also psychological and economic anguish each year. Additionally, silk fibroin is the safest material for tissue engineering due to biocompatibility. In this study, we fabricated hydrocolloid dressings incorporating silk fibroin nanoparticles to enhance the efficacy of hydrocolloid dressing and then use this silk fibroin nanoparticle hydrocolloid dressing (SFNHD) in animal models to treat burn wounds. The structures and properties of SFNHD were characterized using tensile strength and cck-8 assay. The results indicated the structural stability and the cellular biocompatibility of the hydrocolloid dressing suggesting that SFNHD can be applied to the treatment of wounds. To demonstrate the capacity of a silk fibroin hydrocolloid dressing to treat burn wounds, we compared SFNHD to gauze and Neoderm®, a commercially available dressing. This study clearly demonstrated accelerated wound healing with greater wound structural integrity and minimal wound size after treatment with SFNHD. These observations indicate that SFNHD may be an improvement upon current standard dressings such as Gauze and Neoderm® for burn wounds.
and Cooperative Research Program for Agriculture Science & Technology Development (Project No.PJ011214022015), Rural Development Administration, Republic of Korea.
References:
[1] SB Lee, HY Chung, DJ Chung, et al., Effect of calcium alginate dressings on wound healing, Biomat Res , 13, 65 (2009).
[2] A Schneider, XY Wang, DL Kaplan, et al., Biofunctionalized electrospun silk mats as a topical bioactive dressing for accelerated wound healing, Acta Biomat, 5, 2570 (2009).
[3] M Santin, A Motta, G Freddi, et al., In vitro evaluation of the inflammatory potential of the silk fibroin, J Biomed Mater Res, 46, 382 (1999).
Keywords:
Regenerative Medicine,
biomaterial,
biomedical application,
Burn wound
Conference:
10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016.
Presentation Type:
Poster
Topic:
Biomaterials in wound healing
Citation:
Lee
O,
Jung
J,
Khang
G and
Park
C
(2016). Fabrication and characterization of hydrocolloid dressing with silk fibroin nanoparticle for wound healing.
Front. Bioeng. Biotechnol.
Conference Abstract:
10th World Biomaterials Congress.
doi: 10.3389/conf.FBIOE.2016.01.02999
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Received:
28 Mar 2016;
Published Online:
30 Mar 2016.