Obesogens: molecular signaling pathways in fish
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1
CIIMAR - Interdisciplinary center for Marine and Environmental Research, University Porto, Portugal
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2
FCUP, University of Porto, Department of Biology, Portugal
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3
CIIMAR - Interdisciplinary Center of Marine and Environmental Research, University of Porto, Portugal
* santos@ciimar.up.pt; filipe.castro@ciimar.up.pt
In mammals, improper control of lipid metabolism may result in serious health problems such as obesity, increased risk of coronary disease, diabetes and related problems. Recent evidence suggests that many environmental pollutants may be involved in the increased prevalence of obesity. The obesogen hypothesis suggests that human exposure to certain chemicals may damage the mechanisms of body weight control, leading to obesity in adulthood. Here, we will address this issue focusing on the evolution of key molecular players of lipid homeostasis across vertebrates and their improper modulation by environmental chemicals in fish.
Acknowledgements
This work was supported by the project PTDC/MAR/115199/2009 from Fundação para a Ciência e a Tecnologia (Portugal)
Keywords:
Obesogens,
Brain,
Fishes,
mode of action,
Lipid Metabolism
Conference:
XV European Congress of Ichthyology, Porto, Portugal, 7 Sep - 11 Sep, 2015.
Presentation Type:
Oral Presentation
Topic:
Physiology, Behavior and Toxicology
Citation:
Santos
MM,
Lyssimachou
A,
Marques
M,
Capitão
A,
Fonseca
E,
Ruivo
R and
Castro
LF
(2015). Obesogens: molecular signaling pathways in fish.
Front. Mar. Sci.
Conference Abstract:
XV European Congress of Ichthyology.
doi: 10.3389/conf.FMARS.2015.03.00245
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Received:
22 Dec 2015;
Published Online:
24 Dec 2015.
*
Correspondence:
Prof. Miguel M Santos, CIIMAR - Interdisciplinary center for Marine and Environmental Research, University Porto, Porto, Portugal, 4050-123, Portugal, santos@ciimar.up.pt