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PRENATAL DIAGNOSIS OF ESOPHAGEAL ATRESIA: A PROSPECTIVE STUDY

Laura Valfrè1*, Andrea Conforti1, Anita Romiti1, Leonardo Caforio1, Lucia Aite1, Irma Capolupo1 and Pietro Bagolan1
  • 1 Bambino Gesu Children's Hospital, Neonatal Surgery, Italy

AIM: Prenatal suspicious of esophageal atresia (EA) with or without tracheo-esophageal fistula is rare and diagnosis possible only in a minority of cases. Polyhydramnios and small/absent stomach bubble are considered non-specific/indirect signs of potential EA. Aim of our study is to assess the role of upper pouch sign (UPS) in prenatal diagnosis of EA. METHOD: Prospective collected data was performed. We evaluate all prenatal ultrasound scans of fetuses referred for suspected EA between January 2009 and December 2015. We analyzed the presence of small/absent stomach bubble, polyhydramnios and the presence of UPS. Fisher exact test was used as appropriate. RESULTS: Forty patients were referred for suspected EA during the study period. There were 3 terminations of pregnancy, and 3 expectant women were lost before delivery. Thirty-four fetuses were prospectively followed up during pregnancy and reevaluated after birth. Table summarized main results. CONCLUSION: Our data suggest that repeated prenatal evaluation has crucial importance for prenatal diagnosis of EA. Polyhydramnios and UPS are frequently detected in EA patients confirmed postnatally. Temporary detection of polyhydramnios and/or absent/small stomach has no role in prenatally suspicious of EA, while the persistence of those signs are statistically encountered in postnatally confirmed EA patients. Strong prenatal suspicious of EA seems to correlate with high prevalence of LGEA and/or syndromic association.

Keywords: Esophageal Atresia, prenatale diagnosis, Polidramnios, esophageal pouch, Prenatal counselling

Conference: 4th International Conference on Oesophageal Atresia / 15-16 September 2016 / Sydney Australia, Sydney, Australia, 15 Sep - 22 Nov, 2016.

Presentation Type: Poster

Topic: Gastrointestinal morbidity in the OA patient

Citation: Valfrè L, Conforti A, Romiti A, Caforio L, Aite L, Capolupo I and Bagolan P (2017). PRENATAL DIAGNOSIS OF ESOPHAGEAL ATRESIA: A PROSPECTIVE STUDY. Front. Pediatr. Conference Abstract: 4th International Conference on Oesophageal Atresia / 15-16 September 2016 / Sydney Australia. doi: 10.3389/conf.FPED.2017.01.00002

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Received: 15 Sep 2016; Published Online: 11 Dec 2017.

* Correspondence: Dr. Laura Valfrè, Bambino Gesu Children's Hospital, Neonatal Surgery, Rome, Italy, laura.valfre@opbg.net