Injectable PlayFoam like materials for tissue repair
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1
University of California Los Angeles, Chemical and Biomolecular Engineering, United States
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2
University of California Los Angeles, Bioengineering, United States
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3
University of California Los Angeles, Department of Medicine, Dermatology, United States
Stroke is the only major disease without an effective treatment and is the main cause of adult disability in industrialized nations. After ischemic stroke both the brain vasculature and nerves are severely damaged leading to the neurological deficit that causes disability. Better patient prognosis has been linked to increased angiogenesis and overall re-perfusion of the stroke area, indicating that angiogenesis is a critical step towards reducing the neurological deficit and brain repair. Further, active angiogenesis in the peri-infarct zone has been linked to the migration of stem cells from the sub ventricular zone towards the lesion, generating a neurovascular niche. We have designed injectable scaffolds that can further enhance agiogenesis.
However, the hydrogel material utilized for the delivery of our therapeutic drugs was degraded too quickly in vivo. To solve this problem, we have created a new class of injectable biomaterial that circumvents this challenge by providing an interconnected microporous network for simultaneous tissue reformation and material degradation[1]. We assemble monodisperse micro-gel building blocks into an interconnected microporous annealed particle (MAP) scaffold.
Through microfluidic formation, we tailor the chemical and physical properties of the building blocks, providing downstream control of the physical and chemical properties of the assembled MAP scaffold. In vitro, cells incorporated during MAP scaffold formation proliferated and formed extensive 3D networks. In vivo we show enhanced wound closure and cellular infiltration[1].
References:
[1] Griffin DR, Weaver WM, Scumpia PO, Di Carlo D, Segura T. Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks. Nat Mater. 2015 Jul;14(7):737-44. doi: 10.1038/nmat4294. Epub 2015 Jun 1.
Keywords:
biomaterial,
Scaffold,
Tissue Regeneration,
3D scaffold
Conference:
10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016.
Presentation Type:
New Frontier Oral
Topic:
Regenerative medicine: biomaterials for control of tissue induction
Citation:
Segura
T
(2016). Injectable PlayFoam like materials for tissue repair.
Front. Bioeng. Biotechnol.
Conference Abstract:
10th World Biomaterials Congress.
doi: 10.3389/conf.FBIOE.2016.01.00709
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Received:
27 Mar 2016;
Published Online:
30 Mar 2016.