Smart targeted therapy by self-assembled supramolecular nanosystems
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1
the University of Tokyo, Department of Materials Engineering, Japan
Nanotechnology-based medicine (Nanomedicine) has received progressive interest for the treatment of intractable diseases, such as cancer, as well as for the non-invasive diagnosis through various imaging modalities. Engineered polymeric nanosystems with smart functions play a key role in nanomedicine as drug carriers, gene vectors, and imaging probes. This presentation focuses present status and future trends of self-assembled nanosystems from block copolymers for the therapy of intractable diseases.
Nanosystems with 10 to 100 nm in size can be prepared by programmed self-assembly of block copolymers in aqueous entity. Most typical example is polymeric micelles with distinctive core-shell architecture. Several micellar formulations of antitumor drugs have been intensively studied in preclinical and clinical trials, and their utility has been demonstrated. Compared with conventional formulations, such as liposomes, polymeric micelles have several advantages, including controlled drug release, tissue penetrating ability, and reduced toxicity. Critical features of polymeric micelles as drug carriers, including particle size, stability, and loading capacity and release kinetics of drugs, can be modulated by changing structures and physicochemical properties of constituent block copolymers. The development of smart polymeric micelles that dynamically change their properties due to sensitivity to chemical or physical stimuli is the most promising trend toward nanomedicines, directing to the targeting therapy with high efficacy and ensured safety. Notable anti-tumor efficacy against intractable cancer, including pancreatic cancer, of antitumor drug-incorporated polymeric micelles with pH-responding property was demonstrated to emphasize a promising utility of nanomedicines for the cancer treatment.
Versatility in drug incorporation is another feasibility of polymeric micelles. Polymeric micelles loaded with oligonucleotides, including siRNA, have been successfully formulated with relevant properties as nanomedicines such as longevity in blood circulation to reveal significant gene silencing in xenografted as well as spontaneous mice tumor models by systemic injection. These results demonstrate the promising features of polymeric micelles as platform nanosystems for tumor-selective delivery of a variety of molecular-targeted drugs with issues on pharmacokinetics and phramacodynamics.
Keywords:
self-assembly,
Micelle,
Smart material,
targeting delivery
Conference:
10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016.
Presentation Type:
New Frontier Oral
Topic:
Biomaterials for therapeutic delivery
Citation:
Kataoka
K
(2016). Smart targeted therapy by self-assembled supramolecular nanosystems.
Front. Bioeng. Biotechnol.
Conference Abstract:
10th World Biomaterials Congress.
doi: 10.3389/conf.FBIOE.2016.01.01875
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Received:
27 Mar 2016;
Published Online:
30 Mar 2016.
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Correspondence:
Dr. Kazunori Kataoka, the University of Tokyo, Department of Materials Engineering, Tokyo, Japan, Email1