Neuroendocrine regulation of diuresis and anti-diuresis in the Chagas' disease vector, Rhodnius prolixus.
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1
McMaster University, Biology, Canada
Hormones such as neuropeptides and biogenic amines regulate an assortment of biological functions in vertebrates and invertebrates. For insects, one particular biological role regulated by hormones and, of great interest in our research, is the maintenance of salt and water homeostasis. Such regulation is necessary when insects increase food intake, change their metabolism, or are presented with a challenging habitat in which they must either retain or eliminate excess water and/or salts. In the blood-feeder, Rhodnius prolixus, a blood meal which often weighs more than ten times the unfed body weight of the insect is imbibed during each post-embryonic developmental stage. A hormone-regulated rapid diuresis ensues soon after the onset of feeding to remove the excess water and salts associated with the non-nutritive plasma portion of the blood meal. The endogenous hormones leading to the rapid diuresis have been identified and recently a native anti-diuretic factor was also elucidated. We discuss the interplay between these various neuroendocrine-derived factors and their regulation on tissues associated with salt and water balance. The anti-diuretic hormone, RhoprCAPA-2, inhibits serotonin-stimulated diuresis, however, it does not inhibit RhoprCRF-stimulated diuresis. An unexpected finding is that, at concentrations below 100nM, RhoprCAPA-2 augments the diuretic effects of RhoprCRF but attenuates natriuresis.
Acknowledgements
This research was supported by NSERC.
Keywords:
anti-diuresis,
Diuresis,
Homeostasis,
ion,
Neuroendocrinology,
Neurohormone,
Neuropeptide,
Water
Conference:
NASCE 2011: The inaugural meeting of the North American Society for Comparative Endocrinology, Ann Arbor, United States, 13 Jul - 16 Jul, 2011.
Presentation Type:
Invited Symposium
Topic:
Ion and water balance
Citation:
Paluzzi
JV and
O'Donnell
MJ
(2011). Neuroendocrine regulation of diuresis and anti-diuresis in the Chagas' disease vector, Rhodnius prolixus..
Front. Endocrinol.
Conference Abstract:
NASCE 2011: The inaugural meeting of the North American Society for Comparative Endocrinology.
doi: 10.3389/conf.fendo.2011.04.00041
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Received:
11 Jul 2011;
Published Online:
09 Aug 2011.
*
Correspondence:
Dr. Jean-Paul V Paluzzi, McMaster University, Biology, Hamilton, Ontario, L8S4K1, Canada, paluzzi@yorku.ca