Assessment the activity of blood phagocytes at tuberculosis of lungs
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1
Ural Scientyphic Research Institute of traumatology and orthopedics, Ministry of health protection of Russian Federation, Russia
Phagoсitosis is a key element in protection of an organism against tuberculosis mikobakteriya. Studying of possibilities of a flowing cytofluorimetry in an assessment of activity of blood phagocytes of cages at tuberculosis of lungs became the purpose of work. Surveyed 39 people: 14-with an infiltrative form of tuberculosis, 15 - from tuberkuloma, 10 almost healthy people. In work used the CoulterEpicsXL device, Phagotest reagents (Orpegen Pharma), BurstTestKit (Glycotope Biotechnology) and monoclonal antibodies for definition of subpopulations of lymphocytes. Statistical processing is carried out with Statisticа program use. It is established that the assessment activity of blood phagocytes is important criterion of determination of activity of tuberculosis of lungs at early stages of supervision and in the course of treatment, the flowing cytofluorimetry allows quickly, precisely and objectively to estimate activity of blood phagocytes. Tuberculosis of the lungs, being accompanied formation tuberkuloma, is characterized by considerable decrease in number and functional and metabolic activity of neutrophil phagocytes and the monocytes, the expressed reduction of number of T - and B - cells, increase in TNK cells. Infiltrative form of tuberculosis within one share of lungs is accompanied by considerable inflammatory reaction (leycocytosis), decrease in number of T - and B - cells, prevalence of cells with index early activation (CD25+), increase is functional - metabolic activity of neutrophil phagocytes. Markers of early activation of a cage can reflect activity of pathological process and be used for forecasting of a course of tuberculosis of lungs.
Keywords:
туберкулез,
нейтрофилов,
фагоциты,
CD25 +,
B - cells
Conference:
15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.
Presentation Type:
Abstract
Topic:
Immune-mediated disease pathogenesis
Citation:
Berdyugina
OV
(2013). Assessment the activity of blood phagocytes at tuberculosis of lungs.
Front. Immunol.
Conference Abstract:
15th International Congress of Immunology (ICI).
doi: 10.3389/conf.fimmu.2013.02.00006
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Received:
09 Mar 2013;
Published Online:
22 Aug 2013.
*
Correspondence:
Prof. Olga V Berdyugina, Ural Scientyphic Research Institute of traumatology and orthopedics, Ministry of health protection of Russian Federation, Yekaterinburg, Russia, berolga73@rambler.ru