CD30L/CD30 signaling plays a critical role in maintenance and activation of IL-17A-producing γδ T cells in mucosa-associated tissues in mice.
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1
China Medical University, China
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2
University of Miami, United States
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3
Kyushu University, Japan
CD30 ligand (CD30L, CD153), a member of the TNF superfamily, and its receptor CD30 are important for differentiation and activation of CD4+ Th17 cells. In the present report, we demonstrate that the IL-17A-producing γδ T cells normally developed in the fetal thymus, whereas Vγ1-Vγ4- γδ T cells expressed Vγ6/Vδ1 gene transcript selectively decreased in mucosa-associated tissues in naïve CD30KO or CD30LKO mice. Moreover, CD30 and CD30L were expressed preferentially by Vγ1-Vγ4- γδ T cells in naïve mice. The bacteria clearance was attenuated by the impaired response of the IL-17A-producing γδ T cells and decreased infiltration of neutrophils in CD30KO or CD30LKO mice. In vivo administration of agonistic anti-CD30 mAb restored the ability of protection against L. monocytogenes by enhancing Vγ1-Vγ4- γδ T cells producing IL-17A not only in WT but also CD30LKO mice. Taken together, it appears that CD30L/CD30 signaling plays an important role in the maintenance and activation of IL-17A-producing γδ T cells presumably bearing Vγ6 in the mucosa-associated tissues of mice.
Keywords:
innate immunity,
Infection,
IL-17A-producing γδ T cell,
CD30 ligand/CD30,
Mice
Conference:
15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.
Presentation Type:
Abstract
Topic:
Innate immunity
Citation:
SUN
X,
Podack
ER,
Yoshikai
Y and
Lu
C
(2013). CD30L/CD30 signaling plays a critical role in maintenance and activation of IL-17A-producing γδ T cells in mucosa-associated tissues in mice..
Front. Immunol.
Conference Abstract:
15th International Congress of Immunology (ICI).
doi: 10.3389/conf.fimmu.2013.02.00172
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Received:
11 Mar 2013;
Published Online:
22 Aug 2013.
*
Correspondence:
Prof. XUN SUN, China Medical University, Shenyang, China, wsunxun1220@hotmail.com
Prof. Changlong Lu, China Medical University, Shenyang, China, changllu@yahoo.com.cn