Unsuspected relationship between Ferritin Heavy Chain and NK cells tumor susceptibility
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1
University Magna Graecia of Catanzaro, Department of Experimental and Clinical Medicine, Italy
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2
Karolinska Intitutet, Department of Microbiology, Tumor and Cell Biology (MTC), Sweden
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3
University Magna Graecia of Catanzaro, Department of Experimental and Clinical Medicine, Italy
The iron metabolism is crucial for the success of microbial infections. Here, we explored the possible role of iron metabolism in modulating effector immune functions. The ability of pathogens to obtain iron from iron containing proteins of their host is central to whether they live or die.. Ferritin is the major intacellular iron storage protein and serves to store iron in a non-toxic form, to deposit it in a safe form, and to transport it to areas where it is required. Ferritin concentrations increase drastically in the presence of ongoing infection or cancer. Previous work have shown that that ferritin plays a regulatory role immune system homeostasis.
Here we report an ususpected role of Ferritin Heavy Chain (FHC) on tumor immunogenicity and NK cell susceptibility. By using several cancer cell lines in wich FHC was donregulated we have demonstrated an increase in NK tumor cell specific lysis when FHC lack into cells. This is correlate with the downregulation of the Major Histocompatibility Complex Class I (MHC class I), and an increased expression of the two DNAM 1 NK recepror ligands, PVR and NECTIN 2, that we observe in all the downregulated cell lines.
Keywords:
iron metabolism,
Ferritin Heavy Chain,
NK cells,
HLA,
tumor.
Conference:
15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.
Presentation Type:
Abstract
Topic:
Innate immunity
Citation:
Sottile
R,
Santoro
F,
Faniello
CM,
Garofalo
C,
Tallerico
R,
Costanzo
FS and
Carbone
E
(2013). Unsuspected relationship between Ferritin Heavy Chain and NK cells tumor susceptibility.
Front. Immunol.
Conference Abstract:
15th International Congress of Immunology (ICI).
doi: 10.3389/conf.fimmu.2013.02.00394
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Received:
25 Mar 2013;
Published Online:
22 Aug 2013.
*
Correspondence:
Dr. Rosa Sottile, University Magna Graecia of Catanzaro, Department of Experimental and Clinical Medicine, Catanzaro, 88100, Italy, sottiler@mskcc.org