HLA antigens and anti-sperm antibody
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1
Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Iran
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2
Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Iran
Background: In the field of autoimmune disease, anti-sperm antibodies (ASAs) leading to autoimmune male infertility. It is suggested that HLA antigen play key roles in the autoimmune diseases and antibody production. Therefore in this study we evaluated the serum ASA in men after vasectomy and investigated the correlation of ASA production with HLA class I and II in vasectomized men.
Methods: 110 vasectomized and 130 healthy men were examined for ASAs by Gelatin Agglutination Test (Kibrick) and indirect mixed antiglobulin reaction (MAR) test. Also their HLA-A, B, C, DR and -DQ frequency were investigated using microlymphocytotoxicity method in T cells and B cells.
Results: The ASA was detected in 95% vasectomized men, regarding that 53% have an ASA titer of 1/32 or 1/64. Whereas, the levels of ASA only in 13.8% normal men were positive with maximum titer 1/8. No statistically significant correlation was found between the high responder group and frequency of HLA antigens, but a statistically significant correlation was observed in the low responder group and frequency of HLA-A2 and DQw2 antigens
Conclusion: Predisposition to produce ASA seems to be correlated with HLA class I and II antigens, so that men who have HLA-A2 and DQw2 produced lower ASA than other populations, although the better understanding of these findings requires further study.
Keywords:
autoimmune disease,
Anti-sperm antibody,
ASA,
HLA,
Vasectomy
Conference:
15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.
Presentation Type:
Abstract
Topic:
Immune-mediated disease pathogenesis
Citation:
Azizi
G and
Mirshafiey
A
(2013). HLA antigens and anti-sperm antibody.
Front. Immunol.
Conference Abstract:
15th International Congress of Immunology (ICI).
doi: 10.3389/conf.fimmu.2013.02.00527
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Received:
04 Jun 2013;
Published Online:
22 Aug 2013.
*
Correspondence:
Ms. Gholamreza Azizi, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, karaj, Iran, azizi1357g@gmail.com