Immunological, hematological and biochemical parameters are changed in asymptomatic HIV-infected patients, treated or not with antiretroviral drugs
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1
Univ Estadual Paulista - UNESP, Tropical Disease, Brazil
In HIV-infected even during antiretroviral therapy (ART) and absence of symptoms, the imbalance in immunological, hematological and biochemical factors can potentially contribute to progression to AIDS or other comorbidities. We aimed to analyze some of these parameters in 58 asymptomatic HIV-patients: ART-naïve (HIVn, n=18); virologic failure on ART (HIVf, n=18); on ART and complete viral suppression (HIVc, n=22). Quantification of viral load and CD4+ T cells were done by branched-DNA and flow cytometry, respectively. Sandwich immunosorbent assays were performed to quantify cytokines as IFN-g, TNF-a, IL-10 and IL-6. Other results were collected from medical records. Tukey-Kramer test and negative binomial and gamma distributions were calculated (p<0.05). Comparing three groups, we found the lowest levels of IL-10 in HIVc. The HIVf presented the lowest concentration of IFN-g and the highest levels of TNF-a and IL-6. To lymphocytes, mainly CD4+ T, HIVf presented lower counts than other groups. Triglycerides, high-density lipoprotein (HDL) and very low-density lipoprotein (VLDL) were higher in treat-patients (HIVc and HIVf) than HIVn. Total cholesterol was elevated in HIVc when was compared to HIVn, without difference to HIVf. An intriguing result was the higher aspartate-aminotransferase(AST) value found in HIVn than HIVc. When we checked the normal references ranges, the most common changes in the studied population were observed to neutrophils, total leukocytes, hematocrit, creatinine and metabolic exams. Thereby, therapeutic advances have contributed to the slower evolution to AIDS, however the laboratory changes observed in HIV+ deserve to be better understood in order to seek a greater -and better- longevity.
Keywords:
hiv/aids,
Laboratorial changes,
HIV-asymptomatics,
antiretroviral drugs,
Cytokines
Conference:
15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.
Presentation Type:
Abstract
Topic:
Host-pathogen interactions
Citation:
Tasca
KI,
Camargo
CC,
Gatto
M,
Mendes
MB and
Souza
LR
(2013). Immunological, hematological and biochemical parameters are changed in asymptomatic HIV-infected patients, treated or not with antiretroviral drugs.
Front. Immunol.
Conference Abstract:
15th International Congress of Immunology (ICI).
doi: 10.3389/conf.fimmu.2013.02.00552
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Received:
02 May 2013;
Published Online:
22 Aug 2013.
*
Correspondence:
Miss. Karen I Tasca, Univ Estadual Paulista - UNESP, Tropical Disease, Botucatu, SP, Brazil, karenitasca@hotmail.com