Effect of beta-adrenoceptor agonist and antogonist on immune response under thyrotoxicosis
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1
Acad. E.A. Wagner Perm State Medical Academy, immunology, Russia
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2
Institute of Ecology and Genetics of Microorganisms of UB RASciences, Russia
It is known that thyroid hormones may increase the expression of beta-adrenoceptors and/or transduction of intracellular signals in target cells. The aim of this study was to investigate the influence of agonist and antagonist of beta-adrenoceptors on immune response under experimental thyrotoxicosis. Rats were injected L-thyroxine (T4) subcutaneously during 14 days in a daily doses of 0.04 or 4 mg/kg of body weight (b. wt.) for modeling mild or severe forms of thyrotoxicosis respectively. It was established that mortality of rats directly depends on the dose of T4. The increase in number of antibody-forming cells (AFC) and the activation of the delayed type hypersensitivity (DTH) response were revealed under mild form of thyrotoxicosis. The level of AFC and DTH response was decreased under severe form of thyrotoxicosis. The stimulation of AFC response under mild form of thyrotoxicosis was canceled in rats which received the agonist of beta-adrenoceptors (hexoprenaline sulfate i.p. in a daily dose of 0,001 mg/kg b. wt. during 14 days). Hexoprenaline sulfate led to decrease in DTH response level under both forms of thyrotoxicosis. The antagonist of beta-adrenoceptors (sotalol hydrochloride i.p. in a daily dose of 10 mg/kg b. wt. during 14 days) led to cancel of immunosuppression in severe thyrotoxicosis and led to increase in immunostimulation under mild form of thyrotoxicosis. This study was supported by the programs of the Presidium of the Russian Academy of Sciences “Molecular and Cell Biology” and “Fundamental Science for Medicine”.
Keywords:
experimental thyrotoxicosis,
Beta-adrenoceptors,
immune response modifiers,
Delayed type hypersensitivity,
antibody-forming cells
Conference:
15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.
Presentation Type:
Abstract
Topic:
Immune-mediated disease pathogenesis
Citation:
Godovalov
AP and
Shilov
JI
(2013). Effect of beta-adrenoceptor agonist and antogonist on immune response under thyrotoxicosis.
Front. Immunol.
Conference Abstract:
15th International Congress of Immunology (ICI).
doi: 10.3389/conf.fimmu.2013.02.00585
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Received:
11 Jun 2013;
Published Online:
22 Aug 2013.
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Correspondence:
Mr. Anatoliy P Godovalov, Acad. E.A. Wagner Perm State Medical Academy, immunology, Perm, Russia, AGodovalov@gmail.com