Comparison of C3 and C4 with CH50 in North West of Iran
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1
Buali medical diagnostic laboratory, Immunology, Iran
Background and Aim:
The complement system comprises a group of serum proteins and cell membrane receptors that function primarily to fight infection. These components interact in three activation pathways. The central results of activation of these pathways are to deposit the opsonic C3b on bacteria to promote phagocytosis, to lyse bacteria by the assembly of the terminal membrane attack complex and to promote inflammation. The aim of this study was to compare the rate of increase or decrease in C3 and C4 in patients is CH50.
Methods:
This Cross - sectional study on 281 patients referred to the Zanjan’s Clinical Laboratory, C3 and C4 were measured by nephelometry method, CH50 levels were measured using SRID. Then the data were analyzed by the SPSS13 Software.
Results:
The results of tests on patients revealed that, the female: male ratio was 1/16. The mean age of the Patients was 35.31±16.21. (5.5 percent) 15 cases with high C3, (8.7 percent) 24 cases with high C4, (3.4 percent) 9 cases with high CH50. The CH50 data not showed a significant increase in Patients.
Conclusions:
This study showed that CH50 measurements alone cannot be the expression of the complement system function. And other measures such as the complement component like C1q, C3, C4, C5, and C9 with CH50 recommended.
Acknowledgements
Dr Sadr Adin Kalantari soltanieh the head of buali Medical Laboratory
References
North, J. (2005). Complement: measurement. eLS.
Meerasa, A., G Huang, J., and X Gu, F. (2011). CH50: A Revisited Hemolytic Complement Consumption Assay for Evaluation of Nanoparticles and Blood Plasma Protein Interaction. Current Drug Delivery 8, 290-298.
Walport, M., and Woo, P. (1990). Complement.
Keywords:
C3,
C4,
CH50,
nephelometry,
SRID,
Zanjan
Conference:
15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.
Presentation Type:
Abstract
Topic:
Innate immunity
Citation:
Mansoori
B and
Osali
A
(2013). Comparison of C3 and C4 with CH50 in North West of Iran.
Front. Immunol.
Conference Abstract:
15th International Congress of Immunology (ICI).
doi: 10.3389/conf.fimmu.2013.02.00684
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Received:
12 Jun 2013;
Published Online:
22 Aug 2013.
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Correspondence:
Mr. Behzad Mansoori, Buali medical diagnostic laboratory, Immunology, Zanjan, 45138-95515, Iran, B.mansoori_lab@yahoo.com