Cytokines, depression, and anxiety in patients with colorectal cancer
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1
Programa de Pós-graduação em Enfermagem em Saúde Pública. Escola de Enfermagem de Ribeirão Preto, Universidade de São Paulo., Brazil
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2
Programa de Pós-graduação em Imunologia Básica e Aplicada. Faculdade de Medicina de Ribeirão Preto. Universidade de São Paulo., Brazil
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3
Escola de Enfermagem de Ribeirão Preto. Universidade de São Paulo., Brazil
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4
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto. Universidade de São Paulo., Brazil
Colorectal cancer (CRC) is a leading cause of cancer mortality in the world. Depression and anxiety are the most prevalent psychological disorders in patients with CRC. This study aims to investigate whether there is a correlation between anxiety, depression and serum cytokines in CRC patients. The study group consisted of 19 patients hospitalized for surgical resection of CRC and 20 healthy volunteers comprised the control group. Depression and anxiety were analyzed using the Hospital Anxiety and Depression Scale and serum levels of IL-1, IL-6, IL-12, TNF-α, TGF-β and IL-10 were measured by ELISA. We found that approximately 50% of CRC patients manifested clinically significant levels of anxiety and depression or a combination of severe anxiety and depression. Furthermore, these patients had increased serum levels of IL-1, IL-6 and TNF-α, but lower concentrations of IL-12. Analysis of correlation between HADS scores and serum levels of cytokines in CRC patients revealed a positive association of anxiety and/or depression with IL-1, IL-6 and TNF-α and a negative correlation with IL-12. These initial results indicate a correlation between serum levels of pro-inflammatory cytokines, anxiety and depression in CRC patients and suggest that cytokines are involved in the pathophysiology of these comorbidities.
Financial support: Fundação de Amparo à Pesquisa do Estado do São Paulo – FAPESP.
References
1. Dunn J, Lynch B, Rinaldis M, Pakenham K, Mcpherson L, Owen N, Leggett B, Newman B, Aitken J. Dimensions of quality of life and psychosocial variables most salient to colorectal cancer patients. Psycho-Oncology (2006) 15: 20-30.
Keywords:
colorectal cancer,
Anxiety,
Depression,
Cytokines,
Patients
Conference:
15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.
Presentation Type:
Abstract
Topic:
Immune-mediated disease pathogenesis
Citation:
Miranda
DO,
Azevedo
LR,
Lima
TA,
Feres
O,
Rocha
JJ and
Bisson
GS
(2013). Cytokines, depression, and anxiety in patients with colorectal cancer.
Front. Immunol.
Conference Abstract:
15th International Congress of Immunology (ICI).
doi: 10.3389/conf.fimmu.2013.02.00692
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Received:
11 Jun 2013;
Published Online:
22 Aug 2013.
*
Correspondence:
Prof. Gabriela S Bisson, Programa de Pós-graduação em Enfermagem em Saúde Pública. Escola de Enfermagem de Ribeirão Preto, Universidade de São Paulo., Ribeirão Preto, Brazil, gbisson@eerp.usp.br