Exploiting NKG2D and lymphoid stress surveillance response in seronegative spondyloarthritis
-
1
University of Pavia, Italy
-
2
IRCCS University Hospital San Matteo Foundation, Italy
A number of biomarkers are currently being investigated in patients with seronegative spondyloarthitis (SpA) since they may be used to predict exacerbation and monitor the clinical response to an intervention.
Natural killer group 2, member D (NKG2D) is an activating receptor present on the surface of natural killer (NK), CD8 T cells, γδ T cells and under certain conditions CD4 T cells. NKG2D receptor binds to a family of ligands that are distant relatives of major histocompatibility complex class I molecules.
Environmental stress such as genotoxic/oxidative stress, heat shock and viral infections stimulate NKG2D ligands expression. Recent studies have demonstrated that NKG2D ligands are induced on proliferating rheumatoid arthritis (RA) synoviocytes and may thus contribute to progression of rheumatic disease. Here we investigate the expression of NKG2D ligands in synovial tissue from SpA patients and we compare it with samples from RA patients and healthy controls. We monitor NKG2D regulation also in in-vitro cultured SpA and RA synoviocytes in response to physiological stimuli such as oxidative stress, heat-shock and mechanic stretch.
Downregulation of NKG2D receptor on peripheral blood mononuclear cells (PBMC) represents a physiological regulatory mechanism of NK and gd T cells in response to activation and it is mediated by the production of pro-inflammatory proteins. Hence the production of key cytokines by circulating NKG2D+ cells may indicate the impaired response of the immune system to stress in rheumatic disease.
We believe that understanding the contribution of NKG2D pathway in rheumatic pathologies may provide rational for emerging targeted therapies
Keywords:
NKG2D,
NKG2D ligands,
seronegative spondyloarthritis,
lymphoid stress surveillance,
Autoimmunity
Conference:
15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.
Presentation Type:
Abstract
Topic:
Immune-mediated disease pathogenesis
Citation:
Binda
E,
Manzo
A,
Vitolo
B,
Bugatti
S and
Montecucco
C
(2013). Exploiting NKG2D and lymphoid stress surveillance response in seronegative spondyloarthritis.
Front. Immunol.
Conference Abstract:
15th International Congress of Immunology (ICI).
doi: 10.3389/conf.fimmu.2013.02.00712
Copyright:
The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers.
They are made available through the Frontiers publishing platform as a service to conference organizers and presenters.
The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated.
Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed.
For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions.
Received:
13 Jun 2013;
Published Online:
22 Aug 2013.
*
Correspondence:
Dr. Elisa Binda, University of Pavia, Pavia, Italy, elibinda@hotmail.com