Association studies of functional ICOS gene polymorphisms with schizophrenia disease in the Polish population
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1
Institute of Immunology and Experimental Therapy Polish Academy of Sciences, Department of Experimental Therapy, Poland
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2
Wroclaw Medical University, Department and Clinic of Urology, Poland
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3
Wroclaw Medical University, Department of Psychiatry, Poland
Inducible costimulatory molecule (ICOS) which is expressed on the T-cell surface after activation enhances all the basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, the up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B cells.
The study was undertaken to evaluate the association between three ICOS polymorphisms (which were recently described as functional ones) and susceptibility to schizophrenia in a Polish population.
One hundred and fifty patients of schizophrenia and 170 healthy subjects were examined on polymorphisms in the ICOS gene.
Genotyping of the polymorphisms ICOSc.1624C>T, and ICOSc.602A>C and ICOS 2 373G>C was done using allelic discrimination methods with the TaqMan SNP Genotyping Assay.
We noted that frequencies of alleles ICOSc. 1624C>T [C], ICOSc.602A>C [A], and ICOS 2 373G>C [G] were higher in patients of schizophrenia than in healthy controls, but differences did not reach statistical significance (0.930 vs. 0.898, p=0.16; 0.817 vs. 0.777, p=0.21 and 0.889 vs 0.852, p=0.19, respectively).
The result of present study do not strictly confirm the association of investigated polymorphisms with susceptibility to shizophrenia due to small size of studied group, but warrant further investigation through replication studies.
Keywords:
ICOS,
gene polymorphism,
immune system dysregulation,
T-cells,
Schizophrenia
Conference:
15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.
Presentation Type:
Abstract
Topic:
Immune-mediated disease pathogenesis
Citation:
Tomkiewicz
AM,
Karabon
L,
Partyka
AM,
Frydecka
D,
Kiejna
A,
Beszlej
AJ and
Frydecka
I
(2013). Association studies of functional ICOS gene polymorphisms with schizophrenia disease in the Polish population.
Front. Immunol.
Conference Abstract:
15th International Congress of Immunology (ICI).
doi: 10.3389/conf.fimmu.2013.02.00789
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Received:
13 Jun 2013;
Published Online:
22 Aug 2013.
*
Correspondence:
Mrs. Anna M Tomkiewicz, Institute of Immunology and Experimental Therapy Polish Academy of Sciences, Department of Experimental Therapy, Wroclaw, 53-114, Poland, tutak@immuno.iitd.pan.wroc.pl