Some features of cellular immunity in patients with chronic spontaneous urticaria inducing reactivation of chronic EBV infection
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1
Acad. E.A. Wagner Perm State Medical Academy, Russia
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2
I.I. Mechnikov Research Institute for Vaccines and Sera, RAMS, Russia
In the pathogenesis of chronic spontaneous urticaria (CSU) viral infections, including EBV infection often play the role of triggers. The study of EBV-induced diseases is currently an important health problem, due to the spread of the pathogen, its tropism for immune system cells, a variety of clinical forms and nonspecific treatment. To study TLRs expression in patients with CSU as a result of immunotherapy by Immunovac-VP-4 and Kagocel. To assess TLRs expression in PBMC via flow cytometry performed with monoclonal antibodies (Caltag Laboratories, USA). We observed 28 patients with CSU associated with reactivation of chronic EBV infection. CSU patients demonstrated increased as compared to control the levels of TLR2, 4 expression by 3-4 fold exceeding the normal values, while the TLR 3, 9 expression was increased by 2-fold. Immunotherapy by Immunovac-VP-4 was found to enhance the expression of TLR3, 9. After Kagocel therapy the TLR2, 4 expression tended to decrease. TLR3, 9 levels demonstrated the tendency to increase and approached 42,1±3,2 and 33±3,8%, respectively after the treatment. In the group receiving standard treatment, the decrease in TLR4, 3 expression was observed. Immunotherapy by Immunovac-VP-4 and Kagocel led to adjusting for TLR2, 4, and increased TLR3, 9 receptor expression to a more pronounced extent in the group receiving Immunovac-VP-4. Immunotherapy enhanced the TLR9 action, indicating the involvement of intracellular receptor mechanism. Inclusion of immunomodulators in the therapy of patients with CSU associated with reactivation of EBV infection promotes the activation of innate immunity, while increasing the effectiveness of therapy.
Keywords:
chronic spontaneous urticaria,
TLRs expression,
immunomodulators,
chronic EBV infection,
Immunovac-VP-4
Conference:
15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.
Presentation Type:
Abstract
Topic:
Host-pathogen interactions
Citation:
Lebedinskaya
OV,
Sorokina
EA,
Akhmatova
NK and
Akhmatov
EA
(2013). Some features of cellular immunity in patients with chronic spontaneous urticaria inducing reactivation of chronic EBV infection.
Front. Immunol.
Conference Abstract:
15th International Congress of Immunology (ICI).
doi: 10.3389/conf.fimmu.2013.02.00849
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Received:
19 Jun 2013;
Published Online:
22 Aug 2013.
*
Correspondence:
Ms. Olga V Lebedinskaya, Acad. E.A. Wagner Perm State Medical Academy, Perm, Russia, lebedinska@mail.ru