HLA-G influences nasal polyp relapse in HPV positive patients.
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1
Department of Medical Sciences, Section of Microbiology, University of Ferrara, Italy
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2
Operative Unit of Otolaryngology, St. Anna Hospital, Ferrara, Italy
The underlying mechanisms of nasal polyp development have yet to be determined. Human papilloma virus (HPV) infection is considered as a possible candidate, as associated with nasal inverted papilloma (1). HLA-G molecule, an antigen with membrane-bound and soluble isoforms that interact with immune cell inhibitory receptors, is up-modulated by intrleukin-10 (IL-10), an anti-inflammatory cytokine, and increases during viral infection as immune-escape mechanism (2). HPV infection is known to influence IL-10 and HLA-G expression (3), suggesting a possible implication in nasal polyps. We investigated the influence of high risk HPV infection, IL-10 and HLA-G in nasal polyp relapses. We enrolled ten non-allergic patients with nasal polyps and analysed the presence of high-risk HPV by PCR (Sacace), the expression of HLA-G and IL-10 receptor on nasal epithelial cells by immunofluorescence (87G-PE, IL-10R-FITC) and of sHLA-G and IL-10 by ELISA. Our results evidenced high risk HPV infection in 50% of polyps, of which the 80% presented polyp relapse (OR:15). Only HPV positive polyps expressed mHLA-G and IL-10R on epithelial cells. The analysis of nasal epithelial cell culture supernatants showed a correlation between IL-10 and sHLA-G secretion in HPV positive samples. No expression was observed in HPV negative polyps. These data suggest an association between HPV infection, up-modulation of IL-10 and HLA-G expression in nasal epithelial cells and polyp relapses.
Acknowledgements
This work was supported by Fondazione Caricento
References
1. Zaravinos A et al., J Med Virol. 2009;81:1613-9
2. Rizzo R et al. Inflamm Allergy Drug Targets 2012;11:448-63
3. Dong D et al. Reprod Sci 2010;17:718-23
Keywords:
nasal polyp,
HPV,
HLA-G,
IL-10,
relapse
Conference:
15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.
Presentation Type:
Abstract
Topic:
Host-pathogen interactions
Citation:
Rizzo
R,
Bortolotti
D,
Malagutti
N,
Gentili
V,
Rotola
A,
Pezzolo
T,
Fabbri
C,
Aimoni
C,
Pelucchi
S and
Di Luca
D
(2013). HLA-G influences nasal polyp relapse in HPV positive patients..
Front. Immunol.
Conference Abstract:
15th International Congress of Immunology (ICI).
doi: 10.3389/conf.fimmu.2013.02.00882
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Received:
24 Jun 2013;
Published Online:
22 Aug 2013.
*
Correspondence:
Dr. Roberta Rizzo, Department of Medical Sciences, Section of Microbiology, University of Ferrara, Ferrara, Italy, rzr@unife.it