Event Abstract

Heterogeneity and prognostic influence of tumor-infiltrating gamma-delta T lymphocytes in colon cancer patients

  • 1 Dipartimento di Biotecnologie Mediche e Forensi- Università di Palermo, Italy
  • 2 Università degli Studi di Palermo, Dipartimento di Discipline Chirurgiche ed Oncologiche, Italy

Tumors grow in a complex and intricated network of epithelial and mesenchymal cells, inflammatory and immune cells and the characterization of immune contexture is a major prognostic factor for patients survival and represent a target for innovative cancer therapies.
We characterized colon cancer-infiltrating gamma-delta T cells in a cohort of 70 patients in terms of phenotype and effector functions and and correlated the immunological analysis with clinicophatological features of colon cancer. Results show that Vdelta1 T cells were the predominant population in the vast majority of specimens and upon short term mitogen in vitro stimulation produced IL-10, while Vgamma9Vdelta2 T cells were found uniformly at lower proportion in most of the patients, had a predominant terminally-differentiated effector memory (TEMRA) CD45RA+CD27- phenotype, expressed cytotoxic molecules as perforin and granzyme B and upon short term in vitro stimulation with phosphoantigen produced pro-inflammatory cytokines as IL-17 and IFNgamma in different combinations.
Correlation with different clinicopathologic features demonstrates that higher percentage of tumor-infiltrating Vgamma9Vdelta2 T cells are found in well differentiated tumors and in patients with early-stage disease and absence of metastasis, moreover, intratumoral gamma-delta T cell numbers are positively correlated with overall survival of colon cancer patients.
In conclusion, our results highlight the role of gamma-delta T cells against colorectal cancer cells and suggest that immune response mediated by gamma-delta T lymphocytes may contribute to the immunosurveillance of colon cancer. These finding may foster the development of novel alternative or adjuvant therapies targeting gamma-delta T cells for the treatment of colon cancer patients.

Keywords: gamma-delta T cells, Colon Cancer, immunosurveillance, Immunotherapy, tumor immunity

Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.

Presentation Type: Abstract

Topic: Innate immunity

Citation: Lo Presti E, Meraviglia S, Cicero G, Orlando V, Buccheri S, La Manna M, Di Liberto D, Cutrera S, Caccamo N, Dieli F and Dieli F (2013). Heterogeneity and prognostic influence of tumor-infiltrating gamma-delta T lymphocytes in colon cancer patients. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00956

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Received: 27 Jun 2013; Published Online: 22 Aug 2013.

* Correspondence: Dr. Elena Lo Presti, Dipartimento di Biotecnologie Mediche e Forensi- Università di Palermo, Palermo, Italy, elena.lopresti@unipa.it

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