Event Abstract

Heterogeneity and prognostic influence of tumor-infiltrating gamma-delta T lymphocytes in colon cancer patients

  • 1 Dipartimento di Biotecnologie Mediche e Forensi- Università di Palermo, Italy
  • 2 Università degli Studi di Palermo, Dipartimento di Discipline Chirurgiche ed Oncologiche, Italy

Tumors grow in a complex and intricated network of epithelial and mesenchymal cells, inflammatory and immune cells and the characterization of immune contexture is a major prognostic factor for patients survival and represent a target for innovative cancer therapies.
We characterized colon cancer-infiltrating gamma-delta T cells in a cohort of 70 patients in terms of phenotype and effector functions and and correlated the immunological analysis with clinicophatological features of colon cancer. Results show that Vdelta1 T cells were the predominant population in the vast majority of specimens and upon short term mitogen in vitro stimulation produced IL-10, while Vgamma9Vdelta2 T cells were found uniformly at lower proportion in most of the patients, had a predominant terminally-differentiated effector memory (TEMRA) CD45RA+CD27- phenotype, expressed cytotoxic molecules as perforin and granzyme B and upon short term in vitro stimulation with phosphoantigen produced pro-inflammatory cytokines as IL-17 and IFNgamma in different combinations.
Correlation with different clinicopathologic features demonstrates that higher percentage of tumor-infiltrating Vgamma9Vdelta2 T cells are found in well differentiated tumors and in patients with early-stage disease and absence of metastasis, moreover, intratumoral gamma-delta T cell numbers are positively correlated with overall survival of colon cancer patients.
In conclusion, our results highlight the role of gamma-delta T cells against colorectal cancer cells and suggest that immune response mediated by gamma-delta T lymphocytes may contribute to the immunosurveillance of colon cancer. These finding may foster the development of novel alternative or adjuvant therapies targeting gamma-delta T cells for the treatment of colon cancer patients.

Keywords: gamma-delta T cells, Colon Cancer, immunosurveillance, Immunotherapy, tumor immunity

Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.

Presentation Type: Abstract

Topic: Innate immunity

Citation: Lo Presti E, Meraviglia S, Cicero G, Orlando V, Buccheri S, La Manna M, Di Liberto D, Cutrera S, Caccamo N, Dieli F and Dieli F (2013). Heterogeneity and prognostic influence of tumor-infiltrating gamma-delta T lymphocytes in colon cancer patients. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00956

Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters.

The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated.

Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed.

For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions.

Received: 27 Jun 2013; Published Online: 22 Aug 2013.

* Correspondence: Dr. Elena Lo Presti, Dipartimento di Biotecnologie Mediche e Forensi- Università di Palermo, Palermo, Italy, elena.lopresti@unipa.it