Immune markers in oral discomfort patients before and after elimination of oral galvanism
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1
General University Hospital and First Faculty of Medicine, Charles University, Czechia
An enhanced release of metals in the mouth due to galvanic cell formation is considered to be one of the causes of oral discomfort. The aim of this study was to investigate the influence of galvanic cell on salivary immune defense factors. The levels of IgA1, IgA2, secretory IgA, lysozyme and antiIgA/HSP60 were evaluated in representative samples from 159 patients with galvanism, from 177 patients without galvanism and in two control groups. All the participants underwent personal history taking, clinical examination, galvanic currents measurement and saliva collection. Electro active dental materials were removed in 30 patients. There was a significant increase in IgA2 level, a significant decrease in antiIgA/HSP60 levels and an increase in IgA1, secretory IgA and lysozyme levels found after the removal of electro active restorations. Morphological symptoms disappeared in 70 % of the treated patients. The study confirmed that pathologic galvanic phenomena influences the immune defense reactions in the oral cavity and thus deteriorates the symptoms of oral discomfort. A measurement of the galvanism and a subsequent removal of electro active restorations should become a common therapeutic procedure in the patients with oral discomfort.
Acknowledgements
The study was supported by PRVOUK-P28/LF1/6 (Ministry of Education, Youth and Sports, Czech Republic) and by NT 14164-3 and NT 13087-3 (Ministry of Health, Czech Republic).
Keywords:
IgA 1,
IgA2/secretory IgA,
lysozyme,
antiIgA/HSP60,
oral discomfort,
oral galvanism
Conference:
15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.
Presentation Type:
Abstract
Topic:
Adaptive Immunity
Citation:
Podzimek
S,
Tomka
M,
Bartova
J and
Prochazkova
J
(2013). Immune markers in oral discomfort patients before and after elimination of oral galvanism.
Front. Immunol.
Conference Abstract:
15th International Congress of Immunology (ICI).
doi: 10.3389/conf.fimmu.2013.02.00977
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Received:
26 Jun 2013;
Published Online:
22 Aug 2013.
*
Correspondence:
Mr. Stepan Podzimek, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czechia, stepanpodzimek@seznam.cz