Relationship between selenium intake and inflammatory markers in newly-diagnosed patients with B-cell non-Hodgkin lymphoma
-
1
Laboratory of Applied Molecular Biology and Immunology. University of Tlemcen, Algeria
-
2
Haematology Department, Tlemcen Medical Centre University, Algeria
Background: Non-Hodgkin lymphoma (NHL) is the seventh most common cancer in the world. They are malignancies that develop from lymphoid cells. Selenium can modulate the expression of multiple cellular signaling pathways leading to decreased inflammatory gene expression.
Objectives: To determine the relationship between selenium intake and inflammatory markers in newly-diagnosed patients with B-cell NHL.
Materials and Methods: Newly-diagnosed patients with B-cell NHL and healthy age- and sex-matched controls were recruited at the Hematology Department of Tlemcen Medical Centre University (Algeria Northwest) for a retrospective case-control study.
Results: Dietary selenium intake was significantly decreased in patients than in controls, and was significantly correlated with high C-reactive protein (CRP) levels and serum protein electrophoresis patterns. Additionally, oxidant/antioxidant balance was altered in patients.
Conclusion: The reduction of selenium intake induces the synthesis of CRP during the acute phase response in B-cell NHL. Additionally, oxidative stress biomarkers and multi-serum proteomic models may be used for diagnosis and prognosis of the disease.
Acknowledgements
The authors are grateful to patients and subjects for their participation.
Keywords:
Inflammatory markers,
non-Hodgkin lymphoma,
Selenium,
crp,
Serum protein electrophoresis patterns
Conference:
15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.
Presentation Type:
Abstract
Topic:
Immune-mediated disease pathogenesis
Citation:
Aribi
M,
Zahzeh
M,
Hadjidj
Z,
Triqui
C and
Mesli
N
(2013). Relationship between selenium intake and inflammatory markers in newly-diagnosed patients with B-cell non-Hodgkin lymphoma.
Front. Immunol.
Conference Abstract:
15th International Congress of Immunology (ICI).
doi: 10.3389/conf.fimmu.2013.02.01106
Copyright:
The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers.
They are made available through the Frontiers publishing platform as a service to conference organizers and presenters.
The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated.
Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed.
For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions.
Received:
19 Jul 2013;
Published Online:
22 Aug 2013.
*
Correspondence:
Dr. Mourad Aribi, Laboratory of Applied Molecular Biology and Immunology. University of Tlemcen, Tlemcen, Algeria, mourad.aribi@univ-tlemcen.dz