The Dendritic Cells of the Bone Marrow
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1
Burnet Institute, Centre for Biomedical Research, Australia
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2
Monash University, Immunology Department, Australia
Dendritic cells (DC) are antigen presenting cells that are vital for initiating immune responses. They are found throughout the body and within all secondary lymphoid organs however those that might be found in the bone marrow (BM) have not been characterised. Here, for the first time, we reveal the 5 distinct DC subsets found in murine BM. We show that all of these DC subsets display unique functions, including the pathogens they recognise, the type of T cell they activate, and the proinflammatory cytokines and chemokines they produce upon activation. We identify that certain DC subsets of the BM show homology to those found in the spleen through their ability to cross present antigen to CD8 T cells or promote CD4 T cell expansion. However, both phenotypical and functional differences are evident between the DC of both organs. Unlike those of the spleen, certain DC of the BM produce large amounts of the neutrophil chemoattractant CXCL1 suggesting their importance, not only as antigen presenting cells, but as promoters of cell migration to and within the BM microenvironment itself. The BM is known to harbour latent HIV and cytomegalovirus. Recently it has also been shown to be a hideout of Mycobacterium tuberculosis. Our elucidation of the DC subsets within the BM identifies novel cellular targets for clinical manipulation of immune responses within the BM to overcome persistent infections by pathogens such as these. The DC of the BM may also be important targets in the prevention of graft versus host disease.
Keywords:
Bone Marrow,
Dendritic Cells,
Haematopoiesis,
innate immunity,
subset diversification
Conference:
15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.
Presentation Type:
Abstract
Topic:
Innate immunity
Citation:
Fancke
B,
Pooley
J and
O'Keeffe
M
(2013). The Dendritic Cells of the Bone Marrow.
Front. Immunol.
Conference Abstract:
15th International Congress of Immunology (ICI).
doi: 10.3389/conf.fimmu.2013.02.01123
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Received:
12 Jul 2013;
Published Online:
22 Aug 2013.
*
Correspondence:
Mr. Ben Fancke, Burnet Institute, Centre for Biomedical Research, Melbourne, VIC, 3004, Australia, fancke@burnet.edu.au