Study of the inflammatory response in patients with cervicofacial cellulitis
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1
Laboratory od Applied Microbiology in Food, Biomedical and Environnement, University of Tlemcen, Algeria
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2
Laboratory of Applied Molecular Biology and Immunology. University of Tlemcen, Algeria
Introduction: Cervicofacial cellulitis are serious life-threatening infections of the face and neck. The importance of an effective inflammatory response is vital since these diseases are characterized by their rapid deterioration, and more particularly, the risk associated to antibiotics multidrug-resistance in bacteria responsible for these types of infections, such as Streptococcus spp and Staphylococcus aureus. Materials and Methods: From five patients with cervicofacial cellulitis recruited in Hospital of Tlemcen, we have interested to identify Streptococcus bacteria as the main etiological agents responsible for cervicofacial cellulitis of dental origin. In the other hand, we have studied the kinetic of inflammation response in these patients with cervicofacial cellulitis by two methods, CRP measuring and HELENA Serum protein electrophoresis. Results: From patients with cervicofacial cellulitis, we succeeded in the isolation and identification of pathogenic Streptococcus which are Streptococcus pyogenes, Streptococcus pneumonie and Streptococcus agalactiae. From which, it was noted that patient infected with Streptococcus pyogenes present a strong inflammatory response reaction, confirmed by high blood concentration of CRP and significant increases in fractions α1, α2 and γ of serum globulins . While, patient infected by Streptococcus pneumonie and Streptococcus agalactiae had a moderate inflammatory reaction. Conclusion: Study of the inflammatory response in patients with cervicofacial cellulitis by serum protein electrophoresis and assay of an inflammatory marker (CRP) revealed that certain bacterial species especially Streptococcus pneumonie and Streptococcus agalactiae can escape against innate immune defenses, especially due to their polysaccharide capsule, which explains why cellulite cervicofacial disease are characterized by rapid deterioration and high mortality. Therefore, the importance of appropriate antibiotic therapy is very important and vital.
Keywords:
Cervicofacial cellulitis,
Inflammatory Response,
cericofacial cellulitis,
antibiotics-resistant bacteria,
Antibiotics therapy
Conference:
The First International Congress of Immunology and Molecular Immunopathology (CIMIP2014), Tlemcen, Algeria, 17 Oct - 20 Oct, 2014.
Presentation Type:
Poster Presentation
Topic:
Immunomicrobiology
Citation:
Benbelaid
F,
Khadir
M,
Rebiahi
S and
Aribi
M
(2014). Study of the inflammatory response in patients with cervicofacial cellulitis.
Front. Immunol.
Conference Abstract:
The First International Congress of Immunology and Molecular Immunopathology (CIMIP2014).
doi: 10.3389/conf.fimmu.2014.04.00031
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Received:
01 Dec 2014;
Published Online:
01 Dec 2014.
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Correspondence:
Mr. Fethi Benbelaid, Laboratory od Applied Microbiology in Food, Biomedical and Environnement, University of Tlemcen, Tlemcen, 13000, Algeria, benbelaidfethi@gmail.com