The pulse vaccination effects in mammary carcinoma : Mathematical Modeling
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1
Department of Mathematical, University of Tlemcen, Algeria
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2
Laboratory of Applied Molecular Biology and Immunology, University of Tlemcen, Algeria
The artificial immunity, realized through vaccinations, is nowadays a practice widely developed in order to eliminate cancer disease.
We present a mathematical model of the competition between immune system cells and mammary carcinogenesis under the effect of a vaccine (Triplex).
The model describes both the humoral and cellular response of the immune system against cancer cells. The control of the cancer cells growth occurs through the application of the pulse vaccination.
We determine the relation between the strength of the vaccine and the time required to eradicate cancer cells, and we present some examples to illustrate the total depletion of cancer cells influenced by competition occurs among the immune system cells and cancer cells.
Keywords:
Nonlinear ODE,
Immune System,
Mammary Carcinoma,
Pulse vaccination.,
immunoinformatics
Conference:
The First International Congress of Immunology and Molecular Immunopathology (CIMIP2014), Tlemcen, Algeria, 17 Oct - 20 Oct, 2014.
Presentation Type:
Oral Presentation
Topic:
Bioinformatics and Genomics – Immunoinformatics
Citation:
Aboura
C,
Touaoula
M and
ARIBI
M
(2014). The pulse vaccination effects in mammary carcinoma : Mathematical Modeling.
Front. Immunol.
Conference Abstract:
The First International Congress of Immunology and Molecular Immunopathology (CIMIP2014).
doi: 10.3389/conf.fimmu.2014.04.00036
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Received:
30 Nov 2014;
Published Online:
01 Dec 2014.
*
Correspondence:
Mrs. Chahinez Aboura, Department of Mathematical, University of Tlemcen, Tlemcen, 13000, Algeria, abourachanez@yahoo.fr