Low expression of activation and inhibitory molecules on NK cells and CD4+ T-cells is associated with viral control
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1
Universidad de Antioquia, Facultad de Medicina, Colombia
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2
Universidad Cooperativa de Colombia, Colombia
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3
University of Manitoba, Department of Medical Microbiology, Canada
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4
University of Nairobi, Department of Medical Microbiology, Kenya
Chronic human immunodeficiency virus type 1 (HIV-1) infection induces severe immune alterations, including hyperactivation, exhaustion and apoptosis. In fact, viral control has been associated with low frequencies of these processes. Here, we evaluated the expression of activation and inhibitory molecules (CD69, LAG-3, PD-1 and TIM-3) on NK cells subpopulations and CD4+ T-cells and plasma levels of proinflammatory cytokines, including IP-10, TNF-alpha, IFN-gamma, IL-12, IL-13, IL-1beta and G-CSF, in individuals exhibiting viral control: a cohort of HIV-1-exposed-seronegative individuals (HESN) and a cohort of HIV-1-controllers (individuals with spontaneous control of viral replication in absence of HAART). There was lower expression of CD69, LAG-3, PD-1 and TIM-3 in both cohorts when compared to a low-risk population or HIV-1-progressors (individuals HAART-naïve with a CD4+ T-cells count between 300 - 500 cells/µL and plasma viral load between 10.000 - 100.000 viral RNA copies/mL), respectively. In addition, HIV-1-controllers exhibited lower plasma levels of proinflamatory molecules TNF-alpha and IP-10. These findings suggest that individuals exhibiting viral control have lower basal expression of markers associated with cellular activation and particularly immune exhaustion.
Acknowledgements
This investigation was supported by CODI-Universidad de Antioquia “convocatoria mediana cuantía 2011”; Estrategia para Sostenibilidad de Grupos 2014-2015 Universidad de Antioquia; CIHR IID&GH Program of the University of Manitoba; Natalia Taborda received a scholarship from Colciencias “Convocatoria Nacional 511 para el estudio de Doctorado en Colombia año 2010”. Support also from Canadian Institutes for Health Research grant MOP-86721.
Keywords:
HIV-1-controllers,
Hesn,
viral control,
immune activation,
immune exhausting
Conference:
IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología, Medellin, Colombia, 13 Oct - 16 Oct, 2015.
Presentation Type:
Poster Presentation
Topic:
Infectious and parasitic diseases
Citation:
Taborda
NA,
Hernandez
JC,
Lajoie
J,
Juno
JA,
Kimani
J,
Rugeles
MT and
Fowke
K
(2015). Low expression of activation and inhibitory molecules on NK cells and CD4+ T-cells is associated with viral control.
Front. Immunol.
Conference Abstract:
IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología.
doi: 10.3389/conf.fimmu.2015.05.00164
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Received:
20 May 2015;
Published Online:
14 Sep 2015.
*
Correspondence:
Dr. Natalia A Taborda, Universidad de Antioquia, Facultad de Medicina, Medellin, Colombia, nataliataborda@gmail.com
Dr. Juan C Hernandez, Universidad Cooperativa de Colombia, Medellín, Colombia, juankhernandez@gmail.com