Analysis of rs179008 and rs2004640 in Mayan Females with Systemic Lupus Erythematosus from Mexico
Guillermo
Valencia Pacheco1*,
Yumi
E.
Nakazawa Ueji1,
Lizbeth
J.
Gonzalez Herrera2,
Gerardo
J.
Perez Mendoza2,
Darig
Camara Cruz3,
Laureano
D.
Chan Chale3,
Rubi
M.
Velasco Cardenas3,
Angelica
V.
Angulo Ramirez4,
Ricardo
F.
Lopez Villanueva5,
Irma
G.
Quintal Ortiz1,
Ligia
G.
Alonso Salomon1,
Norma
Pavia Ruz1 and
Nubia
A.
Rivero Cardenas1
-
1
Universidad Autonoma de Yucatan, Mexico
-
2
Universidad Autonoma de Yucatan, Mexico
-
3
Univsersidad Autonoma de Yucatan, Facultad de Química, Mexico
-
4
Hospital General Dr. Agustín O’Horán, Servicios de Salud de Yucatán (SSY), Rheumatology, Mexico
-
5
ISSSTE Hospital Regional Mérida, Rheumatology, Mexico
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of worldwide distribution, affecting predominantly women, characterized by presence of humoral and cellular abnormalities influenced by epigenetic and genetic factors. TLR7 and IRF-5, involved in the production of IFN-α, play a role in SLE. There are no genetic studies in the mayan population from Yucatan. Analysis of TLR7 rs179008 and IRF-5 rs2004640 were determined in 108 female patients and 200 healthy females. Frequency of T and A/T y T/T of rs179008 was lower in patients and no association was observed with SLE (OR 0.6527, OR 0.748 and 0.058, respectively). Frequency of T (56 vs 48%) and TT (33 vs 26%) of rs2004640 was higher in patients respect to controls (p = 0.037), Data suggest that rs2004640 is associated with the development of SLE in the mayan female population. Additionally, Expression of IRF5 (mRNA) was analyzed in patients and controls, observing significant increase in patients (p <0.0001). The results suggest the importance of rs2004640 in IRF5 expression and its role in SLE.
Acknowledgements
This work was supported by CONACYT (National Council of Science and Technology), grant FONSEC SALUD 2010-1-'139788
Keywords:
Autoimmunity.,
polimorphisms,
TLR7,
IRF5,
Lupus Erythematosus, Systemic
Conference:
IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología, Medellin, Colombia, 13 Oct - 16 Oct, 2015.
Presentation Type:
Poster Presentation
Topic:
Autoimmunity
Citation:
Valencia Pacheco
G,
Nakazawa Ueji
YE,
Gonzalez Herrera
LJ,
Perez Mendoza
GJ,
Camara Cruz
D,
Chan Chale
LD,
Velasco Cardenas
RM,
Angulo Ramirez
AV,
Lopez Villanueva
RF,
Quintal Ortiz
IG,
Alonso Salomon
LG,
Pavia Ruz
N and
Rivero Cardenas
NA
(2015). Analysis of rs179008 and rs2004640 in Mayan Females with Systemic Lupus Erythematosus from Mexico.
Front. Immunol.
Conference Abstract:
IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología.
doi: 10.3389/conf.fimmu.2015.05.00210
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Received:
15 Apr 2015;
Published Online:
14 Sep 2015.
*
Correspondence:
Dr. Guillermo Valencia Pacheco, Universidad Autonoma de Yucatan, Merida, Yucatan, 97225, Mexico, vpacheco@correo.uady.mx