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Comparative evaluation of the anti-inflammatory effect of two varieties of “Sacha Inchi” (Plukenetia volubilis and Plukenetia huayllabambana) in mice.

JOSE L. AGUILAR1*, Silvia R. Dávila Paico1, Iván A. Lozada-Requena1 and Marco A. Cabello1
  • 1 UNIVERSIDAD PERUANA CAYETANO HEREDIA, Cellular and Molecular Sciences, Peru

The seed of “Sacha Inchi” (Plukenetia spp.) is native from the Peruvian Amazon and it is composed by high level of Omega-3, reaching up to 53% of total fatty acids. The oils of the seeds from two species of Sacha Inchi: Plukenetia volubilis and Plukenetia huayllabambana were evaluated. Different studies have shown that Omega 3 fatty acids can significantly reduce the production of pro-inflammatory molecules. Due to its high content of Omega 3, this research evaluated whether Sacha Inchi oil, is capable of inhibiting or reducing the inflammatory response, comparing the inhibitory capacity of both oils at different concentrations, both in vitro and in vivo experimental animal models. The physicochemical analysis showed that the oil obtained from P. huayllabambana had 53% of Omega 3, while that obtained from P. volubilis had 47%. In the evaluation of cytotoxicity, it was shown that both oils are not cytotoxic, because the Half Maximal Inhibitory Concentration (IC50) values obtained are difficult to achieve in cells. Similarly, in the evaluation of acute toxicity (LD50) both oils were shown to be relatively innocuous, in other words, not toxic to the tested models. Both oils obtained from P. volubilis and P. huayllabambana, shown statistically significant anti-inflammatory effect. Oil obtained from P. huayllabambana, showed best effect, getting to 62% of inhibition of inflammation. Histologically oil higher doses reduced the thickness of the area of tissue inflammation, mainly for P. huayllabambana. Consequently, the safety and potential anti-inflammatory activity of Plukenetia sp. has been demonstrated. Key words: Inflammation, plukenetia, anti-inflammatory products.

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Keywords: Key words: Inflammation, plukenetia, anti-inflammatory products., omega-3, Immunotherapy

Conference: IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología, Medellin, Colombia, 13 Oct - 16 Oct, 2015.

Presentation Type: Oral Presentation

Topic: Immunotherapy

Citation: AGUILAR JL, Dávila Paico SR, Lozada-Requena IA and Cabello MA (2015). Comparative evaluation of the anti-inflammatory effect of two varieties of “Sacha Inchi” (Plukenetia volubilis and Plukenetia huayllabambana) in mice.. Front. Immunol. Conference Abstract: IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología. doi: 10.3389/conf.fimmu.2015.05.00349

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Received: 02 Jun 2015; Published Online: 15 Sep 2015.

* Correspondence: Dr. JOSE L AGUILAR, UNIVERSIDAD PERUANA CAYETANO HEREDIA, Cellular and Molecular Sciences, LIMA, Peru, jose.aguilar@upch.pe