Proteins and neurodegenerative diseases
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1
Hôpital Ambroise Paré, Neurology Department, Belgium
Most neurodegenerative diseases are characterized by the accumulation of proteins in the CNS. For unknown reasons, the proteins which form part of the CNS start to accumulate, aggregate and become “toxic” for the brain.
Depending on the region of the brain in which this accumulation takes place, we see the appearance of different neurodegenerative diseases.
Why do these “good” proteins become killers?
Are all these diseases different or are they just different clinical expressions of the same neuropathological process?
Can understanding this pathological process lead us towards a treatment one day?
The answers in the years to come…
Résumé en français:
La plupart des maladies neurodégénératives sont caractérisées par l’accumulation de protéines dans le cerveau. Pour des raisons encore mal comprises, des protéines utiles pour notre cerveau commencent soudainement à s’accumuler et à devenir toxiques. En fonction de la protéine concernée et de l’endroit du cerveau où elle s’accumule, différentes maladies neurodégénératives apparaissent. Le Dr. Elosegi reviendra sur ces différentes pathologies et sur toutes les questions qui restent aujourd’hui sans réponses et qui font l’objet de recherches intenses au sein des laboratoires belges et internationaux.
Samenvatting in het Nederlands:
De meeste neurodegeneratieve ziektes zijn gekenmerkt door de opeenstapeling van proteïnes in de hersenen. Omwille van redenen die nog altijd niet goed gekend zijn, beginnen nuttige proteïnen zich plots op te stapelen en toxisch te worden. In functie van de betrokken proteïne en de plaats in de hersenen waar ze zich opstapelt, ontstaan diverse neurodegeneratieve ziektes. Dr. Elosegi zal terugblikken op deze diverse pathologieën en op alle onbeantwoord blijvende vragen die momenteel in Belgische en internationale laboratoria onderzocht worden.
Keywords:
Neurodegenerative Diseases,
toxit proteins,
neuropathological process,
Alzheimer Disease,
Parkinson Disease
Conference:
6th Belgian Brain Congress, MONS, Belgium, 8 Oct - 8 Oct, 2016.
Presentation Type:
Oral Presentation
Topic:
Brain and brain diseases: between heredity and environment
Citation:
Elosegi
J
(2016). Proteins and neurodegenerative diseases.
Conference Abstract:
6th Belgian Brain Congress.
doi: 10.3389/conf.fnagi.2016.03.00066
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Received:
13 Jul 2016;
Published Online:
13 Jul 2016.
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Correspondence:
Prof. Jose-Antonio Elosegi, Hôpital Ambroise Paré, Neurology Department, Mons, 7000, Belgium, jose-antonio.elosegi@hap.be