Automated behavioral phenotyping platform for multiple mice
-
1
Weizmann Institute of Science, Neurobiology, Israel
In the recent years there is a growing consensus around the vital importance of developing standardized tools to simultaneously quantify multitude mouse behaviors, in particularly of social behaviors, for studying the genetic and neuronal processes of normal and neuropathological behavioral phenotype in mouse models.
We developed an automated behavioral phenotyping platform for multiple socially-interacting mice under ethological relevant condions. The system comprises of costume-designed hardware and software that recording and integrating the spatial of position of each mouse from 2 sources: 1. Video-based motion tracking dataset and 2. Radio-frequency identified (RFID) based tracking system. This allows tracking the position of multiple mice in large semi-natural enclosure (~200x200cm) in high spatial and temporal resolution (0.5x0.5 cm and 25 time/sec). Furthermore we have developed software that use the mice trajectories to automatically provide large array of the mice behavioral characteristics including of: spatial exploration pattern, anxiety-related behavior, circadian rhythm, social interactions (e.g. chasing, being chased, approach, avoidance) and social hierarchy formation over days period of time.
This novel technology should enable large-scale mouse behavioral phenotyping that can be easily and uniformly applied to any mouse strain and research laboratory. Further this technology should provide robust tool to screen for genes and neuronal circuits regulating social behaviors as well autistic-like symptoms in mouse models.
Keywords:
automated,
Behavior,
Mouse,
novel tool,
phenotype,
social interaction
Conference:
Tenth International Congress of Neuroethology, College Park. Maryland USA, United States, 5 Aug - 10 Aug, 2012.
Presentation Type:
Invited Symposium (only for people who have been invited to a particular symposium)
Topic:
Novel Tools and Methods
Citation:
Vasserman
G,
Kimchi
T and
Weissbrod
A
(2012). Automated behavioral phenotyping platform for multiple mice.
Conference Abstract:
Tenth International Congress of Neuroethology.
doi: 10.3389/conf.fnbeh.2012.27.00026
Copyright:
The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers.
They are made available through the Frontiers publishing platform as a service to conference organizers and presenters.
The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated.
Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed.
For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions.
Received:
26 Apr 2012;
Published Online:
07 Jul 2012.
*
Correspondence:
Dr. Tali Kimchi, Weizmann Institute of Science, Neurobiology, Rehovot, 76100, Israel, tali.kimchi@weizmann.ac.il