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TRP channels in microglia: role in physiology and disease

Maria Juliana Rodriguez1, Santiago Echeverry1 and Yolima P. Torres1*
  • 1 Departamento de Nutrición y Bioquímica, Pontificia Universidad Javeriana, Colombia

Microglia are responsible for modulating the cellular environment in the nervous system, where they have neuroprotective effects. In these cells has been reported the expression of different ion channels, including those belonging to the transient receptor potential (TRP) family. TRP are nonselective cation channels that have six transmembrane domains and both N-terminus and C-terminus domain located in the cytoplasm. These proteins can be activated by mechanical, thermal and chemical stimuli as well as pH changes. Their activation can induce calcium influx contributing to regulate the intracellular calcium concentration. Different studies describe the effect of TRP channels in cellular processes such as osmotic regulation, cytokine production, proliferation, activation, cell death and responses to oxidative stress. As a result, these channels have an important role in neurodegenerative diseases, ischemia, inflammatory responses and pain perception. Modulating the activity of the TRP channels can be a therapeutic target for various diseases associated with the central nervous system. In this review the most relevant aspects about the role of the TRP channels in the physiology of microglia and their potential use as a therapeutic target in central nervous system diseases will be described.

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References

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Keywords: TRP channels, Neurodegenerative Diseases, Microglia, intracellular calcium, Calcium Channels

Conference: Latin-American School on glial cells in the diseased brain (IBRO), Bogotá, Colombia, 13 Jul - 17 Jul, 2015.

Presentation Type: Oral Presentation

Topic: Neurodegenerative diseases

Citation: Rodriguez M, Echeverry S and Torres YP (2015). TRP channels in microglia: role in physiology and disease. Conference Abstract: Latin-American School on glial cells in the diseased brain (IBRO). doi: 10.3389/conf.fncel.2015.35.00022

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Received: 25 Feb 2015; Published Online: 11 Jun 2015.

* Correspondence: Dr. Yolima P Torres, Departamento de Nutrición y Bioquímica, Pontificia Universidad Javeriana, Bogotá, Colombia, ytorres0376@gmail.com