Event Abstract

Neurochemical basis of fear

  • 1 Monash University Malaysia, Brain Research Institute, School of Medicine and Health Sciences, Malaysia

Fear arises in stressful situations that are subjectively perceived as threatening, which is a conserved innate emotion expressed throughout the phyla within the vertebrates. Exposure of humans to an intensely fearful experience can lead to the development of psychological traumatic disorders such as post-traumatic stress disorder, which can be triggered by sight, sound and smell. Predator-derived odors can be highly effective stimuli for eliciting defensive behaviors including fear response in many vertebrates. We have demonstrated the role of a neuropeptide (kisspeptin) in the modulation of odorant (alarm substance)-evoked fear response in a specific brain area, the habenula. Odorant-signals from the olfactory sensory neurons are delivered to the habenular kisspeptin neurons via substance P (tachykinin peptide) containing neurons in the ventral telencephalon to modulate serotonin-dependent fear response. This talk will emphasize the role of kisspeptin and substance P in fear. Understanding neurochemical basis of olfactory related fear circuitry is important to develop treatments for psychological traumatic disorders.

Keywords: Fear, sensory neurons, stress, Kisspeptin, Traumatic injury

Conference: 14th Meeting of the Asian-Pacific Society for Neurochemistry, Kuala Lumpur, Malaysia, 27 Aug - 30 Aug, 2016.

Presentation Type: Plenary Lecture 1

Topic: 14th Meeting of the Asian-Pacific Society for Neurochemistry

Citation: Parhar I (2016). Neurochemical basis of fear. Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00001

Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters.

The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated.

Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed.

For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions.

Received: 26 Jul 2016; Published Online: 11 Aug 2016.

* Correspondence: Prof. Ishwar Parhar, Monash University Malaysia, Brain Research Institute, School of Medicine and Health Sciences, Petaling Jaya, Selangor, Malaysia, ishwar@monash.edu