MK801 improves hippocampal long-term potentiation impairment induced by chronic cerebral hypoperfusion in rat
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1
Universiti Sains Malaysia, Centre for Drug Research, Malaysia
Disorders related to cerebral circulation has become the main reason for any neurological diseases. Blood flow disturbances in the brain may lead to stroke and continuous decrease in blood flow compromises memory. The latter will lead to confusion and progression of dementia. In addition, N-methyl-D-aspartate (NMDA) receptor system in the brain has been implicated in neuronal plasticity, neurotoxicity, learning and memory. The present study aims to evaluate the role of NMDA-receptor system particularly glutamate-mediated long term potentiation (LTP) in the processes of learning and memory formation in chronic cerebral hypoperfusion rats. Cerebral hypoperfusion was developed via permanent ligation of the common carotid arteries to decrease blood flow to the brain. Common carotid arteries of the male Sprague-Dawley rats (250-300g) were permanently ligated (2VO) and sham operated-group were undergone the same surgery without ligation. LTP was recorded on day 28 after surgery in urethane-anesthesized rats. The field excitatory postsynaptic potential (fEPSP) was found to be improved in rats treated with NMDA receptor antagonist, MK801 (0.25mg/kg, intraperitoneal injection) compared to non-treated rats recorded in the hippocampus CA1. The findings confirm the important role of the NMDA-receptor system in reversing the cognitive function of chronic cerebral hypoperfusion rats.
Acknowledgements
Financial support was received from Ministry of Higher Education (MOHE) Malaysia and Universiti Sains Malaysia special funding for the project of Fundamental Neuroscience-Neurobehaviour (304/CDADAH/652201/K134).
Keywords:
Hippocampus,
LTP,
NMDA,
in vivo,
cerebral hypoperfusion
Conference:
14th Meeting of the Asian-Pacific Society for Neurochemistry, Kuala Lumpur, Malaysia, 27 Aug - 30 Aug, 2016.
Presentation Type:
Poster Presentation Session
Topic:
14th Meeting of the Asian-Pacific Society for Neurochemistry
Citation:
Azam
NF and
Hassan
Z
(2016). MK801 improves hippocampal long-term potentiation impairment induced by chronic cerebral hypoperfusion in rat.
Conference Abstract:
14th Meeting of the Asian-Pacific Society for Neurochemistry.
doi: 10.3389/conf.fncel.2016.36.00160
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Received:
04 Aug 2016;
Published Online:
11 Aug 2016.
*
Correspondence:
Dr. Zurina Hassan, Universiti Sains Malaysia, Centre for Drug Research, Minden, Penang, Malaysia, zurina_hassan@hotmail.com