Myelination of the motor nerves in the peripheral nervous system of zebrafish embryos
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1
Korea University Ansan Hospital , Department of Biomedical Sciences, Korea, South
Schwann cells are myelinating-glial cells which ensheath motor nerves with myelin in the peripheral nervous system (PNS). It is necessary for motor neurons to be myelinated for the proper function of neurons such as rapid conduction velocity, protection from environmental toxin and metabolic support of axons. Spinal motor neuron leaves its cell body in spinal cord and extends own axon to PNS for the innervation of muscle fiber. In mammals, motor neurons are classified into several subtypes by the spatiotemporal developmental program. In zebrafish, spinal motor neurons are divided into primary and secondary classes, based on when they differentiate and innervate their target muscle. Primary motor neurons (PMNs), located in the dorsal part of the motor column, are larger, and undergo axogenesis during the first day of development. Secondary motor neurons (SMNs), located more ventrally in the motor column, are smaller, more numerous, appear later and typically have thinner axons than PMNs. However, little is known about relationship of schwann cell myelination pattern with each of these motor neuron subtypes specified from developmental process. In order to investigate the process of the myelination of motor neuron subtypes in the zebrafish spinal cord, we developed the reporter transgenic zebrafish systems to monitor the myelination of motor nerves in vivo. By monitoring the schwann cell myelination of the PMN and SMN, we found that PMN and SMN have distinct myelination pattern during the development of zebrafish embryos.
Keywords:
Peripheral Nervous System,
Zebrafish,
in vivo,
motor,
Myelination
Conference:
14th Meeting of the Asian-Pacific Society for Neurochemistry, Kuala Lumpur, Malaysia, 27 Aug - 30 Aug, 2016.
Presentation Type:
Poster Presentation Session
Topic:
14th Meeting of the Asian-Pacific Society for Neurochemistry
Citation:
Lee
D,
Kim
S,
Kim
E,
Jeong
I,
Kim
H,
Kim
B and
Park
H
(2016). Myelination of the motor nerves in the peripheral nervous system of zebrafish embryos.
Conference Abstract:
14th Meeting of the Asian-Pacific Society for Neurochemistry.
doi: 10.3389/conf.fncel.2016.36.00171
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Received:
04 Aug 2016;
Published Online:
11 Aug 2016.
*
Correspondence:
Mr. Dong-Won Lee, Korea University Ansan Hospital, Department of Biomedical Sciences, Ansan-Si, Gyeonggi-do, Korea, South, ldw0920@hanmail.net