Modeling the Modulation of the Theta and Gamma Oscillations in a small Septo-Hippocampal Network
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1
Humboldt-Universitaet zu Berlin, Germany
Theta (3 - 12 Hz) and gamma (30 - 70 Hz) oscillations in rodent`s hippocampal and septal areas have been throuroughly studied in vivo as well as in vitro. They occur during distinct cognitive states like e.g. free movement or selective perception. Studies revealed that both rhythms exist in isolated CA3 slices [1] wheras in the septum only theta oscillation has been found. In fact, it has been attained [2-4] that the GABAergic connection between both regions contributes to modulate theta and gamma oscillations in the limbic system. This modulation is thought to be achieved by inhibitory input from the septum to inhibitory CA3 interneurons and thus disinhibiting CA3 pyramidal neurons.
The focus of this work is to study the influence of the connection between the septum and the hippocampus CA3 area. On the basis of experimental data and earlier developed models [5,6], we use the Hodgkin-Huxley equations to construct a minimal septo-hippocampal circuit. In our model, we use three hippocampal (CA3) neurons (pyramidal, basket, oriens lacunosum-moleculare) synaptically connected in an all-to-all topology and one septal GABAergic neuron linked with the CA3 basket cell. By changing the synaptic conductances, we extract the range of the coupling strengths at which different patterns emerge and conclude the key parameters for regulating rhythms in our network, in particular theta and gamma. Furthermore, the model is to examine the mechanism of disinhibition and its contribution to the modulation of these oscillation patterns.
References
[1]Hajos N.,Paulsen O.,Neural Networks V.22 1113 (2009)
[2]Buzsaki G. Neuron V.33 325 (2002)
[3]Manseau F.,Goutagny R.,Danik M.,Williams S., J.Neuroscience V.28 4096 (2008);
[4]Toth K.,Borhegyi G.,Freund T.F., J.Neuroscience V.13 3712 (1992);
[5]Gloveli T., Dugladze T.,Rotstein H.,Traub RD. Monyer H.,Heinemann U., Whittington MA.,Kopell N, PNAS V.102 13295 (2005);
[6]Hajos N.,Hoffmann WE., Orban G., Kiss T., Erdi P., Neuroscience V.160 599 (2004)
Keywords:
Hodgkin-Huxley equations,
modulation of rhythms,
septo-hippocampal network,
theta and gamma oscillation
Conference:
BC11 : Computational Neuroscience & Neurotechnology Bernstein Conference & Neurex Annual Meeting 2011, Freiburg, Germany, 4 Oct - 6 Oct, 2011.
Presentation Type:
Poster
Topic:
neurons, networks and dynamical systems (please use "neurons, networks and dynamical systems" as keywords)
Citation:
Milster
S,
Lavrova
A and
Schimansky-Geier
L
(2011). Modeling the Modulation of the Theta and Gamma Oscillations in a small Septo-Hippocampal Network.
Front. Comput. Neurosci.
Conference Abstract:
BC11 : Computational Neuroscience & Neurotechnology Bernstein Conference & Neurex Annual Meeting 2011.
doi: 10.3389/conf.fncom.2011.53.00060
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Received:
23 Aug 2011;
Published Online:
04 Oct 2011.
*
Correspondence:
Mr. Sebastian Milster, Humboldt-Universitaet zu Berlin, Berlin, Germany, smilster@gmail.com