fMRI connectivity within and between resting state networks varies as a function of EEG alpha band synchronization
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1
Radboud University Nijmegen, Netherlands
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2
Max Planck Institute for Psycholinguistics, Netherlands
We studied whether fMRI connectivity within the visual network and between the visual network and the rest of the brain is modulated as a function of posterior alpha EEG power in a resting state session with simultaneous EEG/fMRI recordings. After applying independent component analysis on the EEG data, we selected the central posterior alpha component and used the spontaneous alpha-band fluctuations in this component for further analysis. These fluctuations correlated negatively with the BOLD-signal in the primary visual cortex. This region was used as a seed region for further analysis. Connectivity changes as a function of alpha power between this region and the rest of the brain were assessed by means of a psycho-physiological interaction (PPI) analysis. The 'psychological' variable was constructed by forming high and low alpha power conditions through a median split. For interpretation, the results were compared to a whole brain functional connectivity analysis using the same seed region. The results show that when alpha power increases (1) BOLD connectivity within a network of visual regions decreases and (2) the inverse coupling between the visual cortex and regions of the default mode network (DMN), observed in the functional connectivity analysis weakens. The decreased connectivity within the visual system is in line with the notion that alpha represents functional inhibition, which subsequently results in decreased connectivity between closely connected regions. The decreased negative coupling with the DMN might be related to increased positive coupling when activity in the visual system is low and activity in the DMN is high. Possibly, increased coupling to the DMN serves to prevent inactive regions from interfering with processes in other active regions. Funding: Supported by The Netherlands Organisation for Scientific Research (NWO, grant number 400- 03-277).
Keywords:
alpha band,
multimodal integration
Conference:
XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011.
Presentation Type:
Poster Presentation
Topic:
Poster Sessions: Multimodal Integration of EEG, MEG and fMRI data
Citation:
Scheeringa
R,
Petersson
K,
Jensen
O and
Bastiaansen
MC
(2011). fMRI connectivity within and between resting state networks varies as a function of EEG alpha band synchronization.
Conference Abstract:
XI International Conference on Cognitive Neuroscience (ICON XI).
doi: 10.3389/conf.fnhum.2011.207.00095
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Received:
16 Nov 2011;
Published Online:
25 Nov 2011.
*
Correspondence:
Dr. René Scheeringa, Radboud University Nijmegen, Nijmegen, Netherlands, rene.scheeringa@gmail.com