Role of the subthalamic nucleus (STN) in modulation of cognitive functions: recordings via deep brain stimulation electrodes (DBS)
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1
Masaryk University, Germany
Neuropsychiatric disturbances after DBS indicate the STN involvement in cognitive functions. We report the STN recordings via DBS electrodes in cognitive tasks (Baláž et al., 2008; Rektor et al., 2009; Baláž et al., 2010; Bočková et al., 2011). The STN is implicated in tasks with increased cognitive loads. A dual task but not the simple oddball task evoked local field of P3-like potentials (Baláž et al., 2008). Oscillations in STN were modulated by writing other letter than that which appeared on a screen, but not by simple letter copying (Bočková, in Rektor et al., 2009). In the three stimulus paradigm, the distracter stimulus evoked an early potential (latency 200 ms), not known from the scalp recordings (Bočková et al., 2011). The rTMS of the inferior frontal cortex but not of the dorsolateral prefrontal cortex increased the speed of processing the dual task (Baláž et al., 2010). The STN (1) is implicated in modulation, rather than in a direct regulation, of cognitive functions; (2) there is a spatial overlap of sites regulating various functions, the STN might modulate cognitive activities via contextual modulation of certain cortical areas; (3) implicated in the non-motor activities in some way other than the well-known organisation of the basal ganglia-thalamocortical circuits; direct cortex-STN connexions may play an important role; (4) the modulation of cognitive functions is selective, probably determined by involvement of cortical neuronal population that are interconnected with the STN.
Keywords:
DBS,
Neuropsychiatry
Conference:
XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011.
Presentation Type:
Poster Presentation
Topic:
Poster Sessions: Neuropsychiatric Applications
Citation:
Rektor
I
(2011). Role of the subthalamic nucleus (STN) in modulation of cognitive functions: recordings via deep brain stimulation electrodes (DBS).
Conference Abstract:
XI International Conference on Cognitive Neuroscience (ICON XI).
doi: 10.3389/conf.fnhum.2011.207.00111
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Received:
16 Nov 2011;
Published Online:
25 Nov 2011.
*
Correspondence:
Dr. Ivan Rektor, Masaryk University, Brno, Germany, irektor@med.muni.cz